{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:23:20Z","timestamp":1760646200501,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A relationship between compromised muscles and other tissues has been demonstrated in <jats:italic>mdx<\/jats:italic> mouse, an animal model studied for understanding of Duchenne muscular dystrophy. The hypothesis is that changes in the calcaneal tendon of <jats:italic>mdx<\/jats:italic> mice occur previous to the onset of rigorous and most marked episodes of muscle degeneration, which start suddenly after 21 days of life. Thus, this study aimed to identify possible alterations in the calcaneal tendon of <jats:italic>mdx<\/jats:italic> mouse at 21 days of age. Control and <jats:italic>mdx<\/jats:italic> tendons were submitted to mechanical tensile testing, quantification of hydroxyproline, and staining with toluidine blue and picrosirius red. Hydroxyproline content was similar between <jats:italic>mdx<\/jats:italic> and control groups. The control tendon presented higher mechanical strength (load, stress, and elastic modulus) and its morphological analysis showed a larger number of round fibroblasts, nuclei with well\u2010decondensed chromatin, and slightly metachromatic well\u2010stained cytoplasmic material, different from that observed in <jats:italic>mdx<\/jats:italic> tendons. The results suggest that the absence of dystrophin in <jats:italic>mdx<\/jats:italic> mouse can provoke directly or indirectly alterations in the mechanical properties and morphology of the calcaneal tendon. Anat Rec, 296:1546\u20131551, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22759","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:16:46Z","timestamp":1402291006000},"page":"1546-1551","source":"Crossref","is-referenced-by-count":3,"title":["Mechanical and morphological aspects of the calcaneal tendon of <i>mdx<\/i> mice at 21 days of age"],"prefix":"10.1002","volume":"296","author":[{"given":"Wilson Romero","family":"Nakagaki","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology Institute of Biology, State University of Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Carla","family":"Tomiosso","sequence":"additional","affiliation":[{"name":"Department of Histology Institute of Biomedical Sciences, Federal University of Uberl\u00e2ndia (UFU) Uberl\u00e2ndia MG 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