{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:59:48Z","timestamp":1762459188649,"version":"build-2065373602"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Periodontal disease is an inflammatory disease which constitutes an important health problem in humans due to its enormous prevalence and life threatening implications on systemic health. Routine standard periodontal treatments include gingival flaps, root planning, application of growth\/differentiation factors or filler materials and guided tissue regeneration. However, these treatments have come short on achieving regeneration <jats:italic>ad integrum<\/jats:italic> of the periodontium, mainly due to the presence of tissues from different embryonic origins and their complex interactions along the regenerative process. Tissue engineering (TE) aims to regenerate damaged tissue by providing the repair site with a suitable scaffold seeded with sufficient undifferentiated cells and, thus, constitutes a valuable alternative to current therapies for the treatment of periodontal defects. Stem cells from oral and dental origin are known to have potential to regenerate these tissues. Nevertheless, harvesting cells from these sites implies a significant local tissue morbidity and low cell yield, as compared to other anatomical sources of adult multipotent stem cells. This manuscript reviews studies describing the use of non\u2010oral stem cells in tissue engineering strategies, highlighting the importance and potential of these alternative stem cells sources in the development of advanced therapies for periodontal regeneration. Anat Rec, 297:6\u201315. 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22797","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:17:53Z","timestamp":1402291073000},"page":"6-15","source":"Crossref","is-referenced-by-count":6,"title":["Periodontal Tissue Engineering Strategies Based on Nonoral Stem Cells"],"prefix":"10.1002","volume":"297","author":[{"given":"Jo\u00e3o Filipe","family":"Requicha","sequence":"first","affiliation":[{"name":"3B's Research Group\u2014Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark Guimar\u00e3es Portugal"},{"name":"Department of Veterinary Sciences University of Tr\u00e1s\u2010os\u2010Montes e Alto Douro Vila Real Portugal"},{"name":"ICVS\/3B's\u2014PT Government Associated Laboratory Braga\/Guimar\u00e3es Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"Viegas","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2014Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark Guimar\u00e3es Portugal"},{"name":"Department of Veterinary Sciences University of Tr\u00e1s\u2010os\u2010Montes e Alto Douro Vila Real Portugal"},{"name":"ICVS\/3B's\u2014PT Government Associated Laboratory Braga\/Guimar\u00e3es Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Faculty of Veterinary University of Santiago de Compostela Lugo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui Lu\u00eds","family":"Reis","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2014Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's\u2014PT Government Associated Laboratory Braga\/Guimar\u00e3es Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela Estima","family":"Gomes","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2014Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's\u2014PT Government Associated Laboratory Braga\/Guimar\u00e3es Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.08.017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100448"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240113.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00317.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199803000-00001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2009.0562"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.131"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182077de9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2012.666001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01065.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22316"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2012.01.010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2006.01.010"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00007890-196803000-00009","article-title":"Heterotopic transplants of bone marrow\u2014analysis of precursor cells for osteogenic and hematopoietic tissues","volume":"6","author":"Friedens AJ","year":"1968","journal-title":"Transplantation"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:23:2-3:183"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.89"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.240309797"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.52"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050341"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.7.1239"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.086"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2007.00470.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0380"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2007.00499.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000308480.33644.56"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.9.1281"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090249"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2007.07.004"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2012.42.2.50"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.05.005"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000166547"},{"key":"e_1_2_11_35_1","first-page":"1427","article-title":"Effect of hBMP\u20107 gene modified bone marrow stromal cells on periodontal tissue regeneration","volume":"90","author":"Li YF","year":"2010","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2008.00019.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548-1336-35.3.106"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0025"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190304"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.5.256"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34214"},{"key":"e_1_2_11_42_1","first-page":"B305","article-title":"SHED\u2014Stem cells from human exfoliated deciduous teeth","volume":"82","author":"Miura M","year":"2003","journal-title":"J Dental Res"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.1227"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2004.12.004"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-011-0558-3"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.6.780"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.03204.x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.09.003"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1997.tb01398.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.06.036"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00157.x"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2008.0423"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.026"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-012-9397-0"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01086.x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100596"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200400026"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1996.tb00217.x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16627-0"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-010-0486-7"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.11.021"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00340.x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.54.132"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240902824757"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00484.x"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2005.03.001"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5391.1145"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2007.0048"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.04.071"},{"key":"e_1_2_11_72_1","first-page":"193","article-title":"A utiliza\u00e7\u00e3o de plasma rico em plaquetas (PRP) na regenera\u00e7\u00e3o do osso longo e do osso alveolar. Estudos experimentais num modelo de regenera\u00e7\u00e3o de defeito \u00f3sseo cortical na ovelha (Ovies aries) e num modelo de defeito \u00f3sseo periodontal em c\u00e3o Beagle (Canis familiaris)","volume":"101","author":"Viegas CAA","year":"2006","journal-title":"Rev Portuguesa de Ci\u00eancias Veterin"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24012"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653241003709702"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.05.067"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00362.x"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01119.x"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110267"},{"key":"e_1_2_11_79_1","doi-asserted-by":"crossref","unstructured":"YamadaY NakamuraS ItoK SugitoT YoshimiR NagasakaT UedaM.2010.A feasibility of useful cell\u2010based therapy by bone regeneration with deciduous tooth stem cells dental pulp stem cells or bone\u2010marrow\u2010derived mesenchymal stem cells for clinical study using tissue engineering technology.Tissue Eng A16:1891\u20131900.","DOI":"10.1089\/ten.tea.2009.0732"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070518"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.026"},{"key":"e_1_2_11_82_1","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Thomson JA. 2007. Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu J","journal-title":"Science"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.08.025"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2008.09.004"},{"key":"e_1_2_11_85_1","first-page":"324","article-title":"Effect of the compound of poly lactic\u2010co\u2010glycolic acid and bone marrow stromal cells modified by osteoprotegerin gene on the periodontal regeneration in Beagle dog periodontal defects","volume":"28","author":"Zhou W","year":"2010","journal-title":"West China J Stomatol"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.22797","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.22797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:02:02Z","timestamp":1759928522000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.22797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,2]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/ar.22797"],"URL":"https:\/\/doi.org\/10.1002\/ar.22797","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"type":"print","value":"1932-8486"},{"type":"electronic","value":"1932-8494"}],"subject":[],"published":{"date-parts":[[2013,12,2]]}}}