{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:02:10Z","timestamp":1792098130066,"version":"4.4.0"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Periodontitis, a recognized disease worldwide, is bacterial infection\u2010induced inflammation of the periodontal tissues that results in loss of alveolar bone. Once it occurs, damaged tissue cannot be restored to its original form, even if decontaminating treatments are performed. For more than half a century, studies have been conducted to investigate true periodontal regeneration. Periodontal regeneration is the complete reconstruction of the damaged attachment apparatus, which contains both hard tissue (alveolar bone and cementum) and soft tissue (periodontal ligament). Several treatments, including bone grafts, guided tissue regeneration with physical barriers for epithelial cells, and growth factors have been approved for clinical use; however, their indications and outcomes are limited. To overcome these limitations, the concept of \u201ctissue engineering\u201d was introduced. Combination treatment using cells, growth factors, and scaffolds, has been studied in experimental animal models, and some studies have been translated into clinical trials. In this review, we focus on recent progressive tissue engineering studies and discuss future perspectives on periodontal regeneration. Anat Rec, 297:16\u201325. 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22812","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:17:53Z","timestamp":1402291073000},"page":"16-25","source":"Crossref","is-referenced-by-count":59,"title":["Tissue Engineering in Periodontal Tissue"],"prefix":"10.1002","volume":"297","author":[{"given":"Takanori","family":"Iwata","sequence":"first","affiliation":[{"name":"Institute of Advanced Biomedical Engineering and Science Tokyo Women's Medical University Shinjuku\u2010ku Tokyo Japan"},{"name":"Department of Oral and Maxillofacial Surgery Tokyo Women's Medical University Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yamato","sequence":"additional","affiliation":[{"name":"Institute of Advanced Biomedical Engineering and Science Tokyo Women's Medical University Shinjuku\u2010ku Tokyo 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