{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:54:02Z","timestamp":1761663242973,"version":"build-2065373602"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Introduction: Macroanatomical right\u2010left hemispheric differences in the brain are termed asymmetries, although there is no clear information on the global influence of gender and brain\u2010regions. The aim of this study was to evaluate the main effects and interactions of these variables on the measurement of volumetric asymmetry indices (VAIs). Materials and methods: Forty\u2010seven healthy young\u2010adult volunteers (23 males, 24 females) agreed to undergo brain magnetic resonance imaging in a 3T scanner. Image post processing using voxel\u2010based volumetry allowed the calculation of 54 VAIs from the frontal, temporal, parietal and occipital lobes, limbic system, basal ganglia, and cerebellum for each cerebral hemisphere. Multivariate ANCOVA analysis calculated the main effects and interactions on VAIs of gender and brain regions controlling the effect of age. Results: The only significant finding was the main effect of brain regions (F (6, 9373.605) 44.369, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001; partial \u03b72\u2009=\u2009.101, and power of 1.0), with no significant interaction between gender and brain regions (F (6, 50.517) .239, <jats:italic>P<\/jats:italic>\u2009=\u2009.964). Conclusion: Volumetric asymmetries are present across all brain regions, with larger values found in the limbic system and parietal lobe. The absence of a significant influence of gender and age in the evaluation of the numerous measurements generated by multivariate analyses in this study should not discourage researchers to report and interpret similar results, as this topic still deserves further assessment. Anat Rec, 296:1913\u20131922, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22817","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:23:55Z","timestamp":1402291435000},"page":"1913-1922","source":"Crossref","is-referenced-by-count":7,"title":["Main Effect and Interactions of Brain Regions and Gender in the Calculation of Volumetric Asymmetry Indices in Healthy Human Brains: Ancova Analyses of <i>In Vivo<\/i> 3T MRI Data"],"prefix":"10.1002","volume":"296","author":[{"given":"Ernesto","family":"Roldan\u2010Valadez","sequence":"first","affiliation":[{"name":"MRI Unit Medica Sur Clinic &amp; Foundation Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Rios","sequence":"additional","affiliation":[{"name":"Neurochemistry Department National Institute of Neurology and Neurosurgery Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela A.","family":"Suarez\u2010May","sequence":"additional","affiliation":[{"name":"MRI Unit Medica Sur Clinic &amp; Foundation Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafel","family":"Favila","sequence":"additional","affiliation":[{"name":"GE Healthcare Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Aguilar\u2010Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Cognitive and Behavioral Unit National Institute of Neurology and Neurosurgery Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/0976500X20100101","article-title":"Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication","volume":"1","author":"International Committee of Medical Journal Editors.","year":"2010","journal-title":"J Pharmacol Pharmacother"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520390073019"},{"volume-title":"IBASPM (toolbox for authomatic parcellation of brain structures)","year":"2006","author":"Alem\u00e1n\u2010G\u00f3mez Y","key":"e_1_2_6_4_1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","unstructured":"Alem\u00e1n\u2010G\u00f3mezY Melie\u2010Garc\u00edaL Vald\u00e9s\u2010Hern\u00e1ndezP.2006b.IBASPM: Toolbox for authomatic parcellation of brain structures. 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