{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:22:07Z","timestamp":1773418927854,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Nasopharyngeal carcinoma (NPC) is one of the most common cancers originating in the nasopharynx, and chemoresistance is an essential aspect of NPC chemotherapy failure. Sorcin has been implicated in multidrug resistance (MDR) of many types of human tumor. However, the effect and mechanism of Sorcin in MDR of human NPC is not fully clear. In this report, we silenced Sorcin in human NPC CNE2\/DDP cells, and explored the role of Sorcin in MDR reversal. The results showed an increased cytotoxicity of cisplatin and intracellular accumulation of Rhodamine\u2010123 and glutathione depletion in Sorcin silencing CNE2\/DDP cells. We also found a decreased messenger RNA and protein expression of multidrug resistance gene (<jats:italic>MDR1<\/jats:italic>), multidrug resistance\u2010associated protein (<jats:italic>MRP1<\/jats:italic>), excision repair cross\u2010complementing gene 1 (<jats:italic>ERCC1<\/jats:italic>), glutathione S\u2010transferase\u2010\u03c0 (GST\u2010n), <jats:italic>RhoE<\/jats:italic>, <jats:italic>Bcl\u20102<\/jats:italic>, and <jats:italic>Survivin<\/jats:italic> in Sorcin silencing CNE2\/DDP cells. The increased expression of PTEN and decreased expression of p\u2010Akt and NF\u2010\u03baB suggested that the key cellular signaling pathways were triggered by Sorcin silencing. We concluded that Sorcin silencing would contribute to establish a potent target point for MDR reversal. Anat Rec, 297:215\u2013221, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22832","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:16:31Z","timestamp":1402290991000},"page":"215-221","source":"Crossref","is-referenced-by-count":22,"title":["Reversing Effect of Sorcin in the Drug Resistance of Human Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"297","author":[{"given":"Xuebing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery the Second Hospital of Tianjin Medical University Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery the Second Hospital of Tianjin Medical University Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pathology Tianjin Medical University Cancer Institute and Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Tianjin Huanhu Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800908784293659"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.635646"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9342-5"},{"key":"e_1_2_5_5_1","first-page":"237","article-title":"Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up\u2010regulation of P\u2010gp","volume":"25","author":"He Q","year":"2011","journal-title":"Oncol Rep"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-14541-4_8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.12.044"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.04.004"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22677"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21687"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0384-5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0140-0"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.22832","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.22832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:16:16Z","timestamp":1759947376000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.22832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,24]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/ar.22832"],"URL":"https:\/\/doi.org\/10.1002\/ar.22832","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"value":"1932-8486","type":"print"},{"value":"1932-8494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,24]]}}}