{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:03:08Z","timestamp":1759971788519,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T00:00:00Z","timestamp":1398988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23580403 and 24-2965"],"award-info":[{"award-number":["23580403 and 24-2965"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Paneth cells (PCs) contribute to the host defense against indigenous bacteria in the small intestine. We found Paneth cell\u2010like cells (PLCs) in the rat ascending colon, but the nature of PLCs is never clarified. Therefore, the present study aimed to clarify the cytological characteristics of PLCs and discuss their cellular differentiation. PLCs were localized in the bases of intestinal crypts, especially follicle\u2010associated intestinal crypts in proximal colonic lymphoid tissue, but were very seldom found in the ordinary intestinal crypts of the ascending colon. PLCs possessed specific granules with highly electron\u2010dense cores and haloes, as well as PCs in the small intestine. The secretory granules of PLCs were positive for PAS reaction, lysozyme and soluble phospholipase A2, but negative for Alcian blue staining, \u03b2\u2010defensin\u20101 and \u20102, as well as the ones of PCs. Furthermore, intermediate cells possessing both the PLC\u2010specific granules and the mucus granules similar to those of goblet cells (GCs) were occasionally found in the vicinity of PLCs. Intermediate cells ranged from goblet cell\u2010like cells rich in mucus granules to PLC\u2010like cells with few mucus granules. The cellular condensation and fragmentation were exclusively found in PLCs but never seen in intermediate cells or GCs. The PLCs, which were identified as PC, were suggested to be transformed from GCs through intermediate cells and finally to die by apoptosis in intestinal crypts of proximal colonic lymphoid tissue in the rat ascending colon. Anat Rec, 297:1462\u20131471, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22937","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:35:59Z","timestamp":1402292159000},"page":"1462-1471","source":"Crossref","is-referenced-by-count":10,"title":["Ultrastructural and Histochemical Study on the Paneth Cells in the Rat Ascending Colon"],"prefix":"10.1002","volume":"297","author":[{"given":"Youhei","family":"Mantani","sequence":"first","affiliation":[{"name":"Laboratory of Histophysiology Department of Bioresource Science Graduate School of Agricultural Science, Kobe University 1\u20101 Rokkodai\u2010cho, Nada\u2010ku Kobe Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Nishida","sequence":"additional","affiliation":[{"name":"Laboratory of Histophysiology Department of Bioresource Science Graduate School of Agricultural Science, Kobe University 1\u20101 Rokkodai\u2010cho, 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