{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:30:59Z","timestamp":1789389059992,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:00:00Z","timestamp":1407974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Polish Ministry for Science and Higher Education","award":["N N303 3593 35"],"award-info":[{"award-number":["N N303 3593 35"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myosin VI (MVI) is a unique unconventional myosin translocating, unlike other myosins, towards the minus end of actin filaments. It is involved in numerous cellular processes such as endocytosis, intracellular trafficking, cell migration, and transcription. In mammalian skeletal muscles it localizes mainly to sarcoplasmic reticulum and is also present within the muscle nuclei and at the neuromuscular junction (Karolczak et al. Histochem Cell Biol 2013; 23:219\u2010228). We have also shown that in denervated rat hindlimb muscle the MVI expression level is significantly increased and its localization is changed, indicating an important role of MVI in striated muscle pathology. Here, we addressed this problem by examining the distribution and expression levels of myosin VI in biopsies of skeletal muscles from patients with different myopathies. We found that, particularly in myopathies associated with fiber atrophy, the amount of MVI was enhanced and its localization in affected fibers was changed. Also, since a mutation within the human MVI gene was shown to be associated with cardiomyopathy, we assessed MVI localization and expression level in cardiac muscle using wild type and MLP(\u2212\/\u2212) mice, a dilated cardiomyopathy model. No significant difference in MVI expression level was observed for both types of animals. MVI was found at intercalated discs and also at the sarcoplasmic reticulum. In the knockout mice, it was also present in ring\u2010like structures surrounding the nuclei. The data indicate that in striated muscle MVI could be engaged in sarcoplasmic reticulum maintenance and\/or functioning, vesicular transport, signal transmission and possibly in gene transcription. Anat Rec, 297:1706\u20131713, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22967","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T04:44:53Z","timestamp":1407991493000},"page":"1706-1713","source":"Crossref","is-referenced-by-count":12,"title":["Myosin VI Localization and Expression in Striated Muscle Pathology"],"prefix":"10.1002","volume":"297","author":[{"given":"Justyna","family":"Karolczak","sequence":"first","affiliation":[{"name":"Department of Biochemistry Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Weis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Neuropathology Laboratory of Neuropathology, State Neuropsychiatric Hospital  Linz 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Kami\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jolanta","family":"R\u0119dowicz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology  Warsaw 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