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Several lines of evidence suggest a detrimental role of the inflammatory process in the dystrophic process. Previously, we demonstrated that short\u2010term therapy with eicosapentaenoic acid (EPA), at early stages of disease, ameliorated dystrophy progression in the <jats:italic>mdx<\/jats:italic> mouse. In the present study, we evaluated the effects of a long\u2010term therapy with omega\u20103 later in dystrophy progression. Three\u2010month\u2010old <jats:italic>mdx<\/jats:italic> mice received omega\u20103 (300 mg\/kg) or vehicle by gavage for 5 months. The quadriceps and diaphragm muscles were removed and processed for histopathology and Western blot. Long\u2010term therapy with omega\u20103 increased the regulatory protein MyoD and muscle regeneration and reduced markers of inflammation (TNF\u2010\u03b1 and NF\u2010kB) in both muscles studied. The present study supports the long\u2010term use of omega\u20103 at later stages of dystrophy as a promising option to be investigated in DMD clinical trials. Anat Rec, 298:1589\u20131596, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23177","type":"journal-article","created":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T10:16:34Z","timestamp":1432376194000},"page":"1589-1596","source":"Crossref","is-referenced-by-count":22,"title":["Long\u2010Term Therapy With Omega\u20103 Ameliorates Myonecrosis and Benefits Skeletal Muscle Regeneration in <i>Mdx<\/i> Mice"],"prefix":"10.1002","volume":"298","author":[{"given":"Leticia Montanholi","family":"Apolin\u00e1rio","sequence":"first","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samara Cama\u00e7ari","family":"De Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP Campinas SP 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