{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:18:24Z","timestamp":1771078704733,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002946","name":"German aerospace center (DLR)","doi-asserted-by":"crossref","award":["FKZ 50WBO257"],"award-info":[{"award-number":["FKZ 50WBO257"]}],"id":[{"id":"10.13039\/501100002946","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NSERC Discovery Grant (Canada)","award":["DG 328376"],"award-info":[{"award-number":["DG 328376"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Kinetosis (motion sickness) has been repeatedly shown to affect some fish of a given clutch following the transition from 1g to microgravity or from hypergravity to 1g. This susceptibility to kinetosis may be correlated with irregular inner ear otolith growth. Otoliths are mainly composed of calcium carbonate and matrix proteins, which play an important role in the process of otolith mineralization. Here, we examine the morphology of otoliths and the expression pattern of the major otolith proteins OMP\u20101 and otolin\u20101 in a series of hypergravity experiments. In the utricle, OMP\u20101 is present in centripetal (medial) and centrifugal (lateral) regions of the meshwork area. In the saccule, OMP\u20101 was expressed within a dorsal and a ventral narrow band of the meshwork area opposite to the periphery of the sulcus acusticus. In normal animals, the spatial expression pattern of OMP\u20101 reaches more posteriorly in the centrifugal aspect and is considerably broader in the centripetal portion of the utricle compared to kinetotic animals. However, otolin\u20101 was not expressed in the utricule. In the saccule, no differences were observed for either gene when comparing normal and kinetotically behaving fish. The difference in the utricular OMP\u20101 expression pattern between normally and kinetotically swimming fish indicates a different otolith morphology and thus a different geometry of the otoliths resting on the corresponding sensory maculae. As the utricle is the endorgan responsible for sensing gravity, the aberrant morphology of the utricular otoliths, based on OMP\u20101 expression, likely leads to the observed kinetotic behavior. Anat Rec, 298:1765\u20131773, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23184","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T10:37:57Z","timestamp":1434710277000},"page":"1765-1773","source":"Crossref","is-referenced-by-count":11,"title":["Spatial Expression of Otolith Matrix Protein\u20101 and Otolin\u20101 in Normally and Kinetotically Swimming Fish"],"prefix":"10.1002","volume":"298","author":[{"given":"Jochen","family":"Weigele","sequence":"first","affiliation":[{"name":"Zoological Institute, University of Stuttgart\u2010Hohenheim Garbenstrasse 30 Stuttgart 73734 Germany"},{"name":"Department of Biology Mount Saint Vincent University 166 Bedford Highway Halifax Nova Scotia B3M 2J6 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara A.","family":"Franz\u2010Odendaal","sequence":"additional","affiliation":[{"name":"Department of Biology Mount Saint Vincent University 166 Bedford Highway Halifax Nova Scotia B3M 2J6 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Hilbig","sequence":"additional","affiliation":[{"name":"Zoological Institute, University of Stuttgart\u2010Hohenheim Garbenstrasse 30 Stuttgart 73734 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","unstructured":"AddadiL WeinerS.1985.Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.Proc Natl Acad Sci U S A82:4110\u20134114.","DOI":"10.1073\/pnas.82.12.4110"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"The early morphogenetic development of the cichlid fish, Oreochromis mossambicus (Perciformes,Teleostei)","volume":"231","author":"Anken R","year":"1993","journal-title":"Zool Anz"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00021-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489850154685"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asr.2004.01.024"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asr.2008.07.008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0273-1177(02)00387-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01151-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asr.2003.09.044"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asr.2005.10.027"},{"key":"e_1_2_6_12_1","first-page":"333","article-title":"Influence of gravity on the processing of information by the central nervous system","volume":"5","author":"Cl\u00e9ment G","year":"1995","journal-title":"Proc Eur Symp Life Sci Res Space"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4271(97)00030-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70175-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7863331"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.2.707"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02935558"},{"key":"e_1_2_6_18_1","first-page":"463","article-title":"Swimming behaviour of fish during short periods of weightlessness","volume":"67","author":"DeJong H","year":"1996","journal-title":"Aviat Space Environ Med"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb25250.x"},{"key":"e_1_2_6_20_1","first-page":"947","article-title":"Microgravity effect on the vestibuloocular reflex is dependent on otolith and vision contributions","volume":"67","author":"Grigorova V","year":"1996","journal-title":"Aviat Space Environ Med"},{"key":"e_1_2_6_21_1","unstructured":"HilbigR Sch\u00fcleT IbschM AnkenRH RahmannH.1996. 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