{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:24:39Z","timestamp":1784831079502,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Comparative Histolab"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>New cartilaginous tissues in lizards is formed during the regeneration of the tail or after vertebral damage. In order to understand the origin of new cartilaginous cells in the embryo and after injury of adult vertebrae we have studied the distribution of proliferating cartilaginous cells in the vertebral column of embryos and adults of the lizard <jats:italic>Anolis lineatopus<\/jats:italic> using autoradiography for H3\u2010thymidine and light and ultrastructural immunocytochemistry for 5BrdU. Proliferating sclerotomal cells initially surround the notochord in a segmental pattern and give rise to the chondrocytes of the vertebral centrum that replace the original chordal cells. Qualitative observations show that proliferating sclerotomal cells dilute the labeling up to 13 days post\u2010injection but a few maintain the labeling as long labeling retention cells and remain in the inter\u2010centra and perichondrium after birth. These cells supply new chondroblasts for post\u2010natal growth of vertebrae but can also proliferate in case of vertebral damage or tail amputation in lizards, a process that sustains tail regeneration. The lack of somitic organization in the regenerating tail impedes the re\u2010formation of a segmental vertebral column that is instead replaced by a continuous cartilaginous tube. It is hypothesized that long labeling retaining cells might represent stem\/primordial cells, and that their permanence in the inter\u2010vertebral cartilages and the nearby perichondrium in adult lizards pre\u2010adapt these reptiles to elicit a broad cartilage regeneration in case of injury of the vertebrae. Anat Rec, 299:461\u2013473, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23319","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T12:51:40Z","timestamp":1453294300000},"page":"461-473","source":"Crossref","is-referenced-by-count":12,"title":["Localization of Proliferating Cells in the Inter\u2010Vertebral Region of the Developing and Adult Vertebrae of Lizards in Relation to Growth and Regeneration"],"prefix":"10.1002","volume":"299","author":[{"given":"Lorenzo","family":"Alibardi","sequence":"first","affiliation":[{"name":"Comparative Histolab and Department of Bigea University of Bologna  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"3","article-title":"Development of the axial cartilaginous skeleton in the regenerating tail of lizards","volume":"79","author":"Alibardi 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