{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:51:03Z","timestamp":1759971063754,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171154"],"award-info":[{"award-number":["81171154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Collaborative Innovation Program of Shenzhen","award":["GJHS20120621153317134"],"award-info":[{"award-number":["GJHS20120621153317134"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The purpose of this study was to investigate the feasibility of inducing ocular ischemic syndrome in spontaneously hypertensive rats. Hypertensive and normotensive Wistar\u2013Kyoto rats had bilateral occlusion or sham surgery. They were divided into 4 groups: (1) hypertensive\u2010ischemia, (2) hypertensive\u2010sham, (3) normotensive\u2010ischemia, and (4) normotensive\u2010sham. Four months after the operation, the global changes of the eye and pupillary light reflex were assessed. Then each rat was perfused, and randomly one of the bulbuses oculi was prepared as retinal flat mounts for investigation of vascular changes. The opposite eyeball was prepared as a paraffin section for observation of the linear density of retinal ganglion cells and for thickness measurement. One hypertensive\u2010ischemia rat had a cataract in one eye and another rat in the same group had bulbus oculi collapse in one eye. The light reflex disappeared in 13.33% of hypertensive\u2010ischemia rats, and the rest of the hypertensive\u2010ischemia rats and normotensive\u2010ischemia rats had slow reflex. Compared with the respective controls, the peripheral retinal vascular network in hypertensive\u2010ischemia and normotensive\u2010ischemia rats was sparse; linear density of the retinal ganglion cells was significantly reduced; and the retinal thickness was reduced. Compared with normotensive\u2010ischemia rats, the hypertensive\u2010ischemia rats demonstrated more severe changes. After bilateral common carotic artery occlusion, the eyes of hypertensive rats developed various pathological changes similar to those of ocular ischemic syndrome. In conclusion, an animal model for ocular ischemic syndrome can be created by bilateral common carotid artery occlusion in spontaneously hypertensive rats. Anat Rec, 299:806\u2013814, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23336","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:30:33Z","timestamp":1456457433000},"page":"806-814","source":"Crossref","is-referenced-by-count":7,"title":["Bilateral Common Carotid Artery Occlusion in Spontaneously Hypertensive Rats: A Feasible Animal Model for Ocular Ischemic Syndrome"],"prefix":"10.1002","volume":"299","author":[{"given":"Yacong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology the Fourth Hospital of Shijiazhuang Shijiazhuang Hebei Province 050011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital, Sun Yat\u2010sen University Guangzhou Guangdong Province 510080 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology the Second Hospital of Hebei Medical University Shijiazhuang Hebei Province 050000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Xiang J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology Prince of Wales Hospital, the Chinese University of Hong Kong Shatin New Territories Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology Shijiazhuang Hebei Province 050000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willmann","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medicine, the Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medicine, the Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"T.W. 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