{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:27:44Z","timestamp":1785738464114,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T00:00:00Z","timestamp":1472428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ontario Research Fund-Research Excellence program and Axcelon Biopolymers Corp."},{"name":"Mitacs Elevate Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The fiber arrangement in the pars tensa of the rat tympanic membrane (TM) was observed using a high resolution scanning electron microscope. The entire pars tensa is composed of fibrils with diameter of approximately 25 nm. These fibrils can be grouped into radial, circular, parabolic, and oblique fibers as reported in other mammals. The radial fibrils interweave into a planar form rather than into discrete cylindrical fibers. Before attaching to the manubrium and tympanic ring, the radial fibrils bend and cross neighboring fibrils to form a random fibril network, and change their direction from perpendicular to somewhat parallel to the manubrium and tympanic ring. The circular fibrils form cylindrical fibers near the peripheral part of the TM while closer to the manubrium, they form planar bundles. The observed fiber morphology and arrangement may provide helpful information in improving numerical models for the TM's acoustical response and designing a fibrous graft for the repair of TM perforations. Anat Rec, 299:1531\u20131539, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23461","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T11:32:54Z","timestamp":1471433574000},"page":"1531-1539","source":"Crossref","is-referenced-by-count":6,"title":["Fiber Arrangement in the Rat Tympanic Membrane"],"prefix":"10.1002","volume":"299","author":[{"given":"Jian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemical and Biochemical Engineering Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit K.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics Western University London Ontario Canada"},{"name":"Department of Electrical and Computer Engineering Western University London Ontario Canada"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery London Health Sciences Centre London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanif M.","family":"Ladak","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics Western University London Ontario Canada"},{"name":"Department of Electrical and Computer Engineering Western University London Ontario Canada"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery London Health Sciences Centre London Ontario Canada"},{"name":"Biomedical Engineering Graduate Program Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wankei","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biochemical Engineering Western University London Ontario Canada"},{"name":"Biomedical Engineering Graduate Program Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097247"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.12.024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/000348947808700326","article-title":"Human tympanic membrane\u2013malleus attachment. 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