{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:57:57Z","timestamp":1767841077507,"version":"3.49.0"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009571","name":"Universidad Nacional de San Luis","doi-asserted-by":"publisher","award":["2\u20102614"],"award-info":[{"award-number":["2\u20102614"]}],"id":[{"id":"10.13039\/100009571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The pineal gland of viscacha exhibits histophysiological variations throughout the year, with periods of maximal activity in winter and minimal activity in summer. The aim of this work is to analyze the interstitial cells (IC) in the pineal gland of male viscachas in relation to season and age. The S\u2010100 protein, glio\u2010fibrillary acidic protein (GFAP), and vimentin were detected in adult and immature animals by immunohistochemistry (IHC). Double\u2010IHC was also performed. The S\u2010100 protein was localized within both, IC nucleus and cytoplasm. GFAP was present only in the cytoplasm. Vimentin was expressed in some IC, besides endothelial cells, and perivascular spaces. In the adult males, the morphometric parameters analyzed for the S\u2010100 protein and GFAP exhibited seasonal variations with higher values of immunopositive area percentage in winter and lower values in summer, whereas the immature ones showed the lowest values for all the adult animals studied. Colocalization of S\u2010100 protein and GFAP was observed. The IC exhibited differential expression for the proteins studied, supporting the hypothesis of the neuroectodermal origin. The IC generate an intraglandular communication network, suggesting its participation in the glandular activity regulation processes. The results of double\u2010IHC might indicate the presence of IC in different functional stages, probably related to the needs of the cellular microenvironment. The morphometric variations in the proteins analyzed between immature and adult viscachas probed to be more salient in the latter, suggesting a direct relationship between the expression of the S\u2010100 protein and GFAP, and animal age. Anat Rec, 2017. \u00a9\u20092017 Wiley Periodicals Inc. Anat Rec, 300:1847\u20131857, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23621","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T12:22:39Z","timestamp":1497615759000},"page":"1847-1857","source":"Crossref","is-referenced-by-count":9,"title":["A Seasonal and Age\u2010Related Study of Interstitial Cells in the Pineal Gland of Male Viscacha <i>(Lagostomus maximus maximus)<\/i>"],"prefix":"10.1002","volume":"300","author":[{"given":"Fabricio Ivan","family":"Busolini","sequence":"first","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 5700 San Luis, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Judith","family":"Rosales","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 5700 San Luis, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica Palmira","family":"Filippa","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) 5700 San Luis, Argentina"},{"name":"Histologia, Departamento de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis Avenida Ejercito de los Andes 950, Bloque I, Piso No. 1, San Luis 5700 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian Heber","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Histologia, Departamento de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis Avenida Ejercito de los Andes 950, Bloque I, Piso No. 1, San Luis 5700 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2010.e1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520295.2012.750737"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10718"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20144"},{"key":"e_1_2_6_6_1","unstructured":"Beltr\u00e1nD.2001. 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