{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:51:12Z","timestamp":1759971072241,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Science Research (C), Japan Society for the Promotion of Science","award":["KAKENHI 25460278","17K08501"],"award-info":[{"award-number":["KAKENHI 25460278","17K08501"]}]},{"name":"Grant-in-Aid for Researchers, Hyogo College of Medicine (2015)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The renal nerve plexus comprises efferent and afferent fibers. It controls urine production and bodily fluid homeostasis. Efferent fibers to the kidney include sympathetic nerve fibers from their main ganglia, the prevertebral suprarenal ganglia (SrG), and the paravertebral sympathetic chain ganglia (ChG). In the present study, we examined topological innervation from these ganglia to the renal parenchymal segments of the left kidney of the rat. Fluoro\u2010Gold was injected into the rostral or caudal poles of the left kidney. Approximately 50% of the cells in the SrG of rats injected in the rostral pole were labeled, while 60% of the cells in the ChG T13 of rats injected in the caudal pole were labeled. In addition, we performed dual\u2010probe retrograde tracing of the nerves using two kinds of fluorescent\u2010conjugated cholera toxins (f\u2010CTbs) injected into the rostral and caudal poles of the left kidney. The cells labeled with each f\u2010CTb were distributed differently in the left SrG and the lower ChGs; no dual\u2010labeled cells were found in these ganglia. Anterograde tracing with pCAGGS\u2010tdTomato vector transfected into the left SrG showed that tdTomato\u2010labeled nerve varicosities extended to the cortical arterioles and urinary tubules. Immunohistochemistry revealed that they were positive to tyrosine hydroxylase and synaptophysin, suggesting that they possessed sympathetic nerve endings. Our results show that renal efferent nerves in the SrG may control the rostral part of the kidney and innervate the multiple effectors in the cortex. Anat Rec, 300:2263\u20132272, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23680","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T11:46:40Z","timestamp":1502970400000},"page":"2263-2272","source":"Crossref","is-referenced-by-count":3,"title":["<scp>D<\/scp>ifferential <scp>D<\/scp>istribution of <scp>R<\/scp>enal <scp>N<\/scp>erves in the <scp>S<\/scp>ympathetic <scp>G<\/scp>anglia of the <scp>R<\/scp>at"],"prefix":"10.1002","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-7785","authenticated-orcid":false,"given":"Seishi","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology Hyogo College of Medicine, 1\u20101 Mukogawa, Nishinomiya Hyogo 663\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Fujihira","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Hyogo College of Medicine, 1\u20101 Mukogawa, Nishinomiya Hyogo 663\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Minato","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Hyogo College of Medicine, 1\u20101 Mukogawa, Nishinomiya Hyogo 663\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachi","family":"Kuwahara\u2010Otani","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Hyogo College of Medicine, 1\u20101 Mukogawa, Nishinomiya Hyogo 663\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Hyogo College of Medicine, 1\u20101 Mukogawa, Nishinomiya Hyogo 663\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Immunology and Cell Therapy Hyogo College of Medicine, 1\u20101 Mukogawa, Nishinomiya Hyogo 663\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-8965","authenticated-orcid":false,"given":"Hideshi","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Hyogo College of Medicine, 1\u20101 Mukogawa, Nishinomiya Hyogo 663\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145073"},{"key":"e_1_2_6_3_1","first-page":"1192","article-title":"Innervation of the renal cortex","volume":"37","author":"Barajas L.","year":"1978","journal-title":"Fed Proc"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/y92-098"},{"key":"e_1_2_6_5_1","first-page":"F340","article-title":"Innervation of the thick ascending limb of Henle","volume":"255","author":"Barajas L","year":"1988","journal-title":"Am J Physiol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1984.247.1.F50"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-1605(85)90042-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(93)90046-W"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb12760.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1081\/CEH-100001198"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059002515.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(91)90017-W"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp014006"},{"key":"e_1_2_6_14_1","first-page":"2816","article-title":"Neural regulation of renal tubular sodium reabsorption and renin secretion","volume":"44","author":"DiBona GF.","year":"1985","journal-title":"Fed Proc"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb14811.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0022-3565(25)11354-2","article-title":"Subtype\u2010selective alpha\u20101 adrenoceptor alkylation in the rat kidney and its effect on the vascular pressor response","volume":"260","author":"Elhawary AM","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(86)90034-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00474"},{"key":"e_1_2_6_19_1","first-page":"F189","article-title":"Extrinsic innervation of the rat kidney: A retrograde tracing study","volume":"250","author":"Gattone VH","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135659"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)94116-F"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.05.002"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2011.tb00345.x"},{"key":"e_1_2_6_24_1","first-page":"33","article-title":"The innervation of the adrenal gland. I. The source of pre\u2010 and postganglionic nerve fibres to the rat adrenal gland","volume":"157","author":"Kesse WK","year":"1988","journal-title":"J Anat"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584260"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90319-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00185944"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22652"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.06.026"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.13-0617"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06859"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(89)90093-3"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(84)90076-6"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)32412-2"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.03.020"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21007"},{"key":"e_1_2_6_37_1","first-page":"F957","article-title":"Cells of origin of the sympathetic renal innervation in rat","volume":"252","author":"Sripairojthikoon W","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23179"},{"key":"e_1_2_6_39_1","first-page":"F28","article-title":"Alpha2\u2010adrenoceptors and cellular cAMP levels in single nephron segments from the rat","volume":"249","author":"Umemura S","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs123"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.23680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.23680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ar.23680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.23680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:26:26Z","timestamp":1759926386000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.23680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,28]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/ar.23680"],"URL":"https:\/\/doi.org\/10.1002\/ar.23680","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"type":"print","value":"1932-8486"},{"type":"electronic","value":"1932-8494"}],"subject":[],"published":{"date-parts":[[2017,8,28]]}}}