{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:35:29Z","timestamp":1781624129821,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Herpes simplex virus type I (HSV\u2010I) is a latent neuroinfection which can cause focal brain lesion. The role of HSV\u2010infection in nerve regeneration has not been studied so far. The aim of the work was to study sciatic nerve regeneration in the presence of HSV\u2010infection and the influence of an antiviral drug. BALB\/c line mice were divided into five groups. Group 1 animals were infected with HSV\u2010I. After resolution of neuroinfection manifestations the sciatic nerve of these animals was crushed. Group 2 mice were administered acyclovir following the same procedures. Groups 3\u20135 mice served as controls. Thirty days after the operation distal nerve stumps and <jats:italic>m.gastrocnemius<\/jats:italic> were studied morphologically and biochemically. Ultrastructural organization of the sciatic nerve in control animals remained intact. Morphometric parameters of the nerves from the experimental groups have not reach control values. However, in the group 1 diameter of nerve fibers was significantly smaller than in the group 2. Both nerve regeneration and <jats:italic>m.gastrocnemius<\/jats:italic> reinnervation were confirmed. The muscle hypotrophy was found in groups 1, 2, and 3 (the muscle fibers diameter decreased). Metabolic changes in the muscles of the infected animals (groups 1 and 2) were more pronounced than in control groups 3 and 4. The levels of TBA\u2010active products, conjugated dienes, carbonyl and SH\u2010groups were reduced in <jats:italic>m.gastrocnemius<\/jats:italic> of the experimental groups, however no significant difference associated with acyclovir administration was found. HSV\u2010infection is not limited to the local neurodegenerative changes in the CNS but affects regeneration of the injured sciatic nerve. Anat Rec, 301:1734\u20131744, 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23848","type":"journal-article","created":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T15:40:58Z","timestamp":1525534858000},"page":"1734-1744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nerve Regeneration in Conditions of HSV\u2010Infection and an Antiviral Drug Influence"],"prefix":"10.1002","volume":"301","author":[{"given":"Alla","family":"Gumenyuk","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Bogomolets National Medical University Kyiv 01601 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Rybalko","sequence":"additional","affiliation":[{"name":"Gromashevsky Institute of Epidemiology and Infectious Diseases Kyiv 03038 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alona","family":"Ryzha","sequence":"additional","affiliation":[{"name":"Department of Cytology, Histology and Reproductive Medicine Educational and Scientific Center \u201cInstitute of Biology and Medicine\u201d, Taras Shevchenko Kyiv National University Kyiv 03127 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-2195","authenticated-orcid":false,"given":"Sergey","family":"Savosko","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Bogomolets National Medical University Kyiv 01601 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro","family":"Labudzynskyi","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamins and Coenzymes Biochemistry Palladin Institute of Biochemistry Kyiv 01601 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Levchuk","sequence":"additional","affiliation":[{"name":"Department of Fundamental and Applied Problems of Endocrinology V.P. 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