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The aim of this study was to analyze the mechanical stability and morphological outcome of sutureless repair using fibrin glue conduit and an alternative approach of modified suture placement. Using rat sciatic nerve, we tested the following experimental conditions: conventional suture repair; single suture combined with fibrin glue repair, and fibrin conduit reinforced with modified suture or fibrin glue. Nerve detachment anatomical measures such as axon density, myelin, and fiber caliber were analyzed for evaluation of nerve regeneration. Muscle atrophy were evaluated by muscle wet weight and H&amp;E staining. All animals in sutureless repair group exhibited complete detachment or elongation by two or four weeks after repair. No detachment was found in any other groups. Animals treated with fibrin conduit reinforced with modified suture showed better axonal regeneration with good alignment. There were no significant differences in axon caliber among the groups. Muscle atrophy was found in all groups and there was no significant difference in muscle wet\u2010weight among the groups. In summary, sutureless nerve repair with fibrin glue was mechanically unstable for resistance of mechanical stretches, fibrin glue conduit with modified suture placement is mechanically stable and resulted in better morphological outcome. Anat Rec, 301:1690\u20131696, 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23921","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T03:18:34Z","timestamp":1540351114000},"page":"1690-1696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Nerve Repair With Fibrin Nerve Conduit and Modified Suture Placement"],"prefix":"10.1002","volume":"301","author":[{"given":"Wenjin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery University Hospital Basel  CH\u20104031 Basel Switzerland"},{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Degrugillier","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic 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