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This approach relies on the concept that entheseal bone morphology is influenced by cumulative biomechanical stress. A fundamental criterion for assessing the stage of entheseal change involves the proportion of elevated bone area. However, it is not yet clear if bone elevation is associated with biomechanical forces exerted during physical activity, while the histology of the entheses of the human hand, the least\u2010bodyweight\u2010bearing anatomical area, is not fully investigated. Multiple previous studies on entheses have concluded that the concentration of calcified fibrocartilage reflects the level of applied forces. On this basis, if hand entheseal surface elevation was associated with the level of biomechanical stress, then a greater amount of calcified fibrocartilage would be expected in entheses' central and more projecting bone areas. More importantly, individual entheses with a greater proportion of elevated bone areas would present a higher total concentration of calcified fibrocartilage. To test these hypotheses, this pilot study conducted a histological quantitative analysis on two thumb entheses of four fully\u2010documented body donors. Across individuals, all central entheseal regions presented greater calcified fibrocartilage, while the entheses showing additional bone elevation in their marginal areas comprised substantially higher total values. The observations of this small\u2010scale pilot study support the concept that interindividual differences in entheseal bone morphology are related to varying levels of biomechanical loading. Furthermore, they encourage future research to compile larger sample sizes, for comparing individuals with distinct lifelong activities. Anat Rec, 302:1093\u20131103, 2019. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.23984","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T18:15:16Z","timestamp":1539800116000},"page":"1093-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Is Bone Elevation in Hand Muscle Attachments Associated with Biomechanical Stress? 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