{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:32:22Z","timestamp":1790440342116,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE025033"],"award-info":[{"award-number":["DE025033"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Natural model systems evolving under extreme environmental pressures provide the opportunity to advance our knowledge of how the craniofacial complex evolves in nature. Unlike traditional models, natural systems are less inbred, and, therefore, better model the complex variation of the human population. Owing to the nature of certain craniofacial aberrations in blind Mexican cavefish, we suggest that this organism can provide new insights to a variety of craniofacial changes. Diverse cranial features have evolved in natural cave\u2010dwelling <jats:italic>Astyanax<\/jats:italic> fish, which have thrived in the unforgiving darkness and nutrient\u2010poor environment of the cave for countless generations. While the genetic and environmental underpinnings of various cranial anomalies have been investigated for decades, a comprehensive characterization of their molecular and developmental origins remains incomplete. Cavefish provide numerous advantages given the availability of genomic resources, developmental and molecular tools, and the presence of a normative surface\u2010dwelling \u201cancestral\u201d surrogate for comparative studies. By leveraging the frequency of abnormal and asymmetric cranial features in cavefish, we anticipate advances in our knowledge of the etiologies of irregular cranial features. Extreme adaptations in cavefish are expected to offer new insights into the complex and multifactorial nature of craniofacial disorders and facial asymmetry. Anat Rec, 2018. \u00a9 2018 American Association for Anatomy.<\/jats:p>","DOI":"10.1002\/ar.23998","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T10:43:31Z","timestamp":1540550611000},"page":"24-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Natural Animal Model System of Craniofacial Anomalies: The Blind Mexican Cavefish"],"prefix":"10.1002","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0032-1053","authenticated-orcid":false,"given":"Joshua B.","family":"Gross","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Cincinnati  312 Clifton Court, Rieveschl Hall Room 711B, Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda K.","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Cincinnati  312 Clifton Court, Rieveschl Hall Room 711B, Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420-9101.2005.01007.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2008.11.006"},{"key":"e_1_2_4_4_1","first-page":"263","article-title":"Revisi\u00f3n del g\u00e9nero Anoptichthys con descipi\u00f3n de una especie nueva (Pisces, Characidae)","volume":"4","author":"Alvarez J","year":"1946","journal-title":"An Esc Nac Cien Biol Mexico"},{"key":"e_1_2_4_5_1","first-page":"215","article-title":"Descripcion de Anoptichthys hubbsi caracindo ciego de La Cueva de Los Sabinos","volume":"8","author":"Alvarez J","year":"1947","journal-title":"S L P Rev Soc Mexicana Hist Nat"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510802112"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080823"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1107239"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110314"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23682"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.03.020"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2014.1005"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-5138(03)00084-9"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-41324-2_7"},{"key":"e_1_2_4_15_1","first-page":"193","volume-title":"The evolution of the cavefish craniofacial complex. 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