{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:11:52Z","timestamp":1759950712798,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Romanian National Authority for Scientific Research and Innovation, CNCS - UEFISCDI","award":["PN-II-RU-TE-2014-4-1811"],"award-info":[{"award-number":["PN-II-RU-TE-2014-4-1811"]}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The presence of hyaline cartilage has been previously documented in heart tissue of different vertebrates, ranging from birds to superior mammals. However, there is scarce published data regarding the appearance of focal deposits of hyaline\u2010like cartilage within the hearts of laboratory rats. Few mechanisms that could trigger the appearance of this type of cartilage in heart were hypothesized (e.g., mechanical stress, ageing). Using different microscopy techniques this report confirms the presence of hyaline cartilage and bone in Wistar rats, which underwent left anterior coronary artery ligation for experimental myocardial infarction. The presented (ultra)structural evidence of focal chondroid metaplasia in the papillary muscles and close to the insertion point in the ventricular mass of the infarcted heart suggests a structural adaptation of cardiac myocardium to the newly acquired kinetics of left ventricular wall, after experimental myocardial infarction. Specific cartilaginous matrix proteins are known to mediate cardiac extracellular matrix remodeling, and this study provides evidence of a complete transition to a cartilaginous pattern in postinfarcted heart, which may nonetheless constitute a supplemental risk factor of a further heart failure condition. Moreover, for heart focal chondrogenesis, we also presume the involvement of the cellular and molecular inflammatory milieu that dominates the first 24 hr border zone landscape of the experimental myocardial infarction lesion. Anat Rec, 302:947\u2013953, 2019. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.24010","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T07:44:25Z","timestamp":1540712665000},"page":"947-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Areas of Cartilaginous and Osseous Metaplasia After Experimental Myocardial Infarction in Rats"],"prefix":"10.1002","volume":"302","author":[{"given":"Catalin Gabriel","family":"Manole","sequence":"first","affiliation":[{"name":"Animal Facility Department, \u201cVictor Babe\u015f\u201d National Institute of Pathology  99\u2010101 Splaiul Independe\u0163ei, 050096 Bucharest Romania"},{"name":"Histology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy  8 Eroilor Sanitari Blvd., 050474 Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan Gabriel","family":"Marinescu","sequence":"additional","affiliation":[{"name":"Animal Facility Department, \u201cVictor Babe\u015f\u201d National Institute of Pathology  99\u2010101 Splaiul Independe\u0163ei, 050096 Bucharest Romania"},{"name":"Faculty of Veterinary Medicine University of Agronomic Sciences  59 M\u0103r\u0103\u015fti Blvd., 011464 Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daciana","family":"Marta","sequence":"additional","affiliation":[{"name":"Ultrastructural Pathology Department \u201cVictor Babe\u015f\u201d National Institute of Pathology  99\u2010101 Splaiul Independen\u0163ei, 050096 Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-1166","authenticated-orcid":false,"given":"Mihnea Ioan","family":"Nicolescu","sequence":"additional","affiliation":[{"name":"Histology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy  8 Eroilor Sanitari Blvd., 050474 Bucharest Romania"},{"name":"Radiobiology Department \u201cVictor Babe\u015f\u201d National Institute of Pathology  99\u2010101 Splaiul Independen\u0163ei, 050096 Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.17795\/jmb-8480"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2016.02.016"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.44.163"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2008.06.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2014.a26"},{"volume-title":"Developing insights in cartilage repair","year":"2013","author":"Caron MMJ","key":"e_1_2_6_7_1"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Cartilaginous and osseous metaplasia in the aortic valve","volume":"4","author":"Chen M","year":"2006","journal-title":"Internet J Cardiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4849"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)91956-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0021-8782.2004.00326.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2011.08.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2000.19630485.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","unstructured":"GerdesAM.2012.Chapter 5: Cardiomyocyte ultrastructure. 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