{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:12:37Z","timestamp":1790187157071,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY014263"],"award-info":[{"award-number":["EY014263"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The organization of extraocular muscles (EOMs) and their motor nuclei was investigated in the mouse due to the increased importance of this model for oculomotor research. Mice showed a standard EOM organization pattern, although their eyes are set at the side of the head. They do have more prominent oblique muscles, whose insertion points differ from those of frontal\u2010eyed species. Retrograde tracers revealed that the motoneuron layout aligns with the general vertebrate plan with respect to nuclei and laterality. The mouse departed in some significant respects from previously studied species. First, more overlap between the distributions of muscle\u2010specific motoneuronal pools was present in the oculomotor nucleus (III). Furthermore, motoneuron dendrites for each pool filled the entire III and extended beyond the edge of the abducens nucleus (VI). This suggests mouse extraocular motoneuron afferents must target specific pools based on features other than dendritic distribution and nuclear borders. Second, abducens internuclear neurons are located outside the VI. We concluded this because no unlabeled abducens internuclear neurons were observed following lateral rectus muscle injections and because retrograde tracer injections into the III labeled cells immediately ventral and ventrolateral to the VI, not within it. This may provide an anatomical substrate for differential input to motoneurons and internuclear neurons that allows rodents to move their eyes more independently. Finally, while soma size measurements suggested motoneuron subpopulations supplying multiply and singly innervated muscle fibers are present, markers for neurofilaments and perineuronal nets indicated overlap in the size distributions of the two populations. Anat Rec, 302:1865\u20131885, 2019. \u00a9 2019 American Association for Anatomy<\/jats:p>","DOI":"10.1002\/ar.24141","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T22:14:05Z","timestamp":1555452845000},"page":"1865-1885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mouse Extraocular Muscles and the Musculotopic Organization of Their Innervation"],"prefix":"10.1002","volume":"302","author":[{"given":"Martin O.","family":"Bohlen","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Duke University  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Neurobiology &amp; Anatomical Sciences University of Mississippi Medical Center  Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Stahl","sequence":"additional","affiliation":[{"name":"Neurology Service Cleveland Department of Veterans Affairs Medical Center  Cleveland Ohio"},{"name":"Department of Neurology Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Neurobiology &amp; Anatomical Sciences University of Mississippi Medical Center  Jackson Mississippi"},{"name":"Department of Ophthalmology University of Mississippi Medical Center  Jackson Mississippi"},{"name":"Department of Neurology University of Mississippi Medical Center  Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3050-8094","authenticated-orcid":false,"given":"Susan","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Neurobiology &amp; Anatomical Sciences University of Mississippi Medical Center  Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901810405"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.4.391"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18716"},{"key":"e_1_2_7_5_1","unstructured":"BohlenMO WarrenS BlumerR StahlJS MayPJ.2014.The organization of extraocular muscle motoneuronal pools in the mouse. 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