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Larger MNs innervate fast fatigue\u2010intermediate (FInt) or fast\u2010fatiguable (FF) muscle fibers in type FInt and FF motor units, respectively. Smaller MNs innervate slow\u2010twitch fatigue\u2010resistant (S) or fast fatigue\u2010resistant (FR) muscle fibers in type S and FR motor units, respectively. In amyotrophic lateral sclerosis (ALS), FInt and FF motor units are more vulnerable, with denervation and MN death occurring for these units before the more resilient S and FR units. Abnormal MN dendritic arbors have been observed in ALS in humans and rodent models. We used a Golgi\u2010Cox impregnation protocol to examine soma size\u2010dependent changes in the dendritic morphology of lumbar MNs in SOD1\n                    <jats:sup>G93A<\/jats:sup>\n                    mice, a model of ALS, at pre\u2010symptomatic, onset and mid\u2010disease stages. In wildtype control mice, the relationship between MN soma surface area and dendritic length or dendritic spine number was highly linear (i.e., increased MN soma size correlated with increased dendritic length and spines). By contrast, in SOD1\n                    <jats:sup>G93A<\/jats:sup>\n                    mice, this linear relationship was lost and dendritic length reduction and spine loss were observed in larger MNs, from pre\u2010symptomatic stages onward. These changes correlated with the neuromotor symptoms of ALS in rodent models. At presymptomatic ages, changes were restricted to the larger MNs, likely to comprise vulnerable FInt and FF motor units. Our results suggest morphological changes of MN dendrites and dendritic spines are likely to contribute ALS pathogenesis, not compensate for it. Anat Rec, 303:1455\u20131471, 2020. \u00a9 2019 American Association for Anatomy\n                  <\/jats:p>","DOI":"10.1002\/ar.24255","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T11:44:07Z","timestamp":1568202247000},"page":"1455-1471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Size\u2010Dependent Vulnerability of Lumbar Motor Neuron Dendritic Degeneration in SOD1\n                    <sup>G93A<\/sup>\n                    Mice"],"prefix":"10.1002","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-6612","authenticated-orcid":false,"given":"Matthew J.","family":"Fogarty","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences The University of Queensland  St Lucia Queensland Australia"},{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic  Rochester 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