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While statins are a reported cause of myopathy, some studies have suggested that statins could potentially ameliorate dystrophy due to their pleiotropic effects on inflammation, myonecrosis, and autophagy. In the present study, we evaluated the potential benefit of rosuvastatin treatment on heart, limb, and diaphragm muscles in dystrophin\u2010deficient <jats:italic>mdx<\/jats:italic> mice at an early stage (45\u2009days of age) of disease. <jats:italic>Mdx<\/jats:italic> mice received rosuvastatin (10 mg\/kg) by gavage for 30\u2009days beginning at 15\u2009days of age. Normal C57BL\/10 mice received rosuvastatin by the same route over the same interval. In the <jats:italic>mdx<\/jats:italic> group, rosuvastatin significantly increased IgG\u2010positive fibers (myonecrosis) and the inflammatory areas in the biceps brachii and diaphragm muscles and decreased the anterior limb muscle force (grip strength). Molecular markers of inflammation (TNF\u2010\u03b1 and NF\u2010kB) and fibrosis (fibronectin) were not altered by rosuvastatin in <jats:italic>mdx<\/jats:italic> mice skeletal and cardiac muscles. In normal mice, rosuvastatin increased CK, TNF\u2010\u03b1 (heart), NF\u2010kB (diaphragm), and fibronectin (heart and diaphragm). Inflammatory areas were seen in all normal muscles of rosuvastatin\u2010treated mice. Rosuvastatin did not benefit dystrophy in the <jats:italic>mdx<\/jats:italic> mice and was associated with inflammation in normal cardiac and skeletal muscles.<\/jats:p>","DOI":"10.1002\/ar.24341","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T11:20:02Z","timestamp":1576754402000},"page":"2202-2212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardiac and skeletal muscle changes associated with rosuvastatin therapy in dystrophic <i>mdx<\/i> mice"],"prefix":"10.1002","volume":"303","author":[{"given":"J\u00falia M.G.","family":"Finkler","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology Institute of Biology, University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samara C.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Institute of Biology, University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto","family":"Santo Neto","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Institute of Biology, University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4894-4401","authenticated-orcid":false,"given":"Maria J.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Institute of Biology, University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787315729"},{"key":"e_1_2_6_3_1","first-page":"6(4)","article-title":"Taurine and methylprednisolone administration at close proximity to the onset of muscle degeneration is ineffective at attenuating force loss in the hind\u2010limb of 28\u2009days mdx mice","volume":"30","author":"Barker R. 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