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It is detected in 35% of children less than 2\u2009years of age, but absent in the healthy adult lung. Environmental gases or allergens may have an effect on the number of BALT. Lungs of rhesus macaque monkeys were screened by histology for the presence, size, and location of BALT after exposure to filtered air for 2, 6, 12, or 36\u2009months or 12 and 36\u2009months to ozone or 2, 12, or 36\u2009months of house dust mite or a combination of ozone and house dust mite for 12\u2009months. In the lungs of monkeys housed in filtered air for 2\u2009months, no BALT was identified. After 6, 12, or 36\u2009months, the number of BALT showed a significantly increased correlation with age in monkeys housed in filtered air. After 2\u2009months of episodic house dust mite (HDM) exposure, no BALT was found. Monkeys exposed to HDM or HDM\u2009+\u2009ozone did not show a significant increase in BALT compared to monkeys housed in filtered air. However, monkeys exposed to ozone alone did show significant increases in BALT compared to all other groups. In particular, there were frequent accumulations of lymphocytes in the periarterial space of ozone exposed animals. In conclusion, BALT in rhesus monkeys housed under filtered air conditions is age\u2010dependent. BALT significantly increased in monkeys exposed to ozone in comparison with monkeys exposed to HDM.<\/jats:p>","DOI":"10.1002\/ar.24456","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T09:52:07Z","timestamp":1590227527000},"page":"2766-2773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Organized lymphatic tissue (<scp>BALT<\/scp>) in lungs of rhesus monkeys after air pollutant exposure"],"prefix":"10.1002","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-2606","authenticated-orcid":false,"given":"Reinhard","family":"Pabst","sequence":"first","affiliation":[{"name":"Institute of Immunomorphology, Centre of Anatomy Medical School of Hannover  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Miller","sequence":"additional","affiliation":[{"name":"California National Primate Research Center  Davis 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