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The ramified networks of epithelial tubules it establishes are critical for the processes of secretion, excretion and exchange mediated by these tissues. In the kidney, branching serves to establish the collecting duct system that transports urine from the nephrons into the renal pelvis, ureter and finally the bladder. Generally speaking, the formation of these networks in different organs begins with the specification and differentiation of simple bud\u2010like organ anlage, which then undergo a process of elaboration, typically by bifurcation. This process is often governed by the interaction of progenitor cells at the tips of the epithelia with neighboring mesenchymal cell populations which direct the branching process and which often themselves differentiate to form part of the adult organ. In the kidney, the tips of ureteric bud elaborate through a dynamic cell signaling relationship with overlying nephron progenitor cell populations. These cells sequentially commit to differentiation and the resulting nephrons reintegrate with the ureteric epithelium as development progresses. This review will describe recent advances in understanding the how the elaboration of the ureteric bud is patterned and consider the extent to which this process is shared with other organs.<\/jats:p>","DOI":"10.1002\/ar.24486","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T09:39:35Z","timestamp":1597311575000},"page":"2578-2587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Branching morphogenesis as a driver of renal development"],"prefix":"10.1002","volume":"303","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-008X","authenticated-orcid":false,"given":"Kieran M.","family":"Short","sequence":"first","affiliation":[{"name":"Department of Anatomy and Developmental Biology Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-7829","authenticated-orcid":false,"given":"Ian M.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.09.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80514-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.02.033"},{"key":"e_1_2_9_5_1","first-page":"601","article-title":"Morphometric index of the developing murine kidney. 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