{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:50:43Z","timestamp":1787619043580,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31200897"],"award-info":[{"award-number":["31200897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To explore the possible mechanism of weight loss in Parkinson's disease (PD). Bilateral injections of 6\u2010hydroxydopamine (6\u2010OHDA) into substantia nigra (SN) were performed to induce the PD model rats. The rotarod test, food intake, body weight, and interscapular brown adipose tissue (IBAT) weight were recorded 6\u2009weeks postoperation. HE staining was performed to observe the morphology of multilocular adipose cells in IBAT. Immunohistochemistry and western blot were used to determine the protein levels of tyrosine hydroxylase (TH) in the SN, and the levels of uncoupling protein 1 (UCP1), peroxisome proliferator\u2010activated receptor gamma coactivator\u20101\u03b1 (PGC\u20101\u03b1), phosphorylated\u2010hormone sensitive lipase (p\u2010HSL), HSL, TH, \u03b23\u2010adrenergic receptor (\u03b23\u2010AR), cyclic adenosine monophosphate (cAMP), and protein kinase A (PKA) in IBAT. After treatment with 6\u2010OHDA for 6\u2009weeks, 6\u2010OHDA rats exhibited decreased TH expression in SN accompanied with shortened staying time on the rotating rod. This motor impairment paralleled with no significant alteration in body mass, IBAT weight, and food intake until the end of the experimental protocol. However, the decreasing diameter of the single fat vesicle in IBAT was observed in the 6\u2010OHDA group. Meanwhile, compared with the control group, the protein expression of UCP1, PGC\u20101\u03b1, p\u2010HSL, TH, \u03b23\u2010AR, cAMP, and PKA in IBAT were increased significantly in the 6\u2010OHDA group, whereas no obvious change in the expression of HSL. The present study suggested an increased energy expenditure and activation of the \u03b23\u2010AR\u2010cAMP\u2010PKA signaling pathway in the IBAT after the destruction of the dopamine system in the SN of the rat.<\/jats:p>","DOI":"10.1002\/ar.24505","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T05:37:30Z","timestamp":1598852250000},"page":"704-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased energy expenditure and activated <scp>\u03b23\u2010AR\u2010cAMP\u2010PKA<\/scp> signaling pathway in the interscapular brown adipose tissue of <scp>6\u2010OHDA<\/scp>\u2010induced Parkinson's disease model rats"],"prefix":"10.1002","volume":"304","author":[{"given":"Hui","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences Xinxiang Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences Xinxiang Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences Xinxiang Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Hai","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences Xinxiang Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences Xinxiang Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Hao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of MRI The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-9158","authenticated-orcid":false,"given":"Zhi\u2010Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences Xinxiang Medical University  Xinxiang China"},{"name":"Xinxiang Key Laboratory of Molecular Neurology Xinxiang Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00406.2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90195-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.182"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90133-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2652"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9642524"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.11.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13807"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01470-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3233\/JPD-181386","article-title":"Weight loss in Parkinson's disease: No evidence for role of small intestinal bacterial overgrowth","volume":"8","author":"DiBaise J. 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