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A total of 19 embryonic and fetal samples were carefully dissected and microscopically analyzed. Neural tube closure was observed between 7.5 and 8\u2009days of gestation. Primordial encephalic vesicle differentiation and spinal canal delimitation were observed on the 12th day of gestation. Histologically, on the 15th day of gestation, the brain, cerebellum, and brain stem were delimited. On the 18th day of gestation, the cervical and lumbar intumescences of the spinal cord were visible. On the 28th day of gestation, four\u2010cell layers could be distinguished in the cerebral cortex, while the cerebellar cortex was still differentiating. Overall, the morphological aspects of the embryonic and fetal developmental phases in rabbits were highly similar to those in humans. Thus, the present study provides relevant information highlighting rabbits as an excellent candidate animal model for preclinical research on human neurological diseases given the high adaptability of rabbits to bioterium conditions and the similarity of morphological events between rabbits and humans.<\/jats:p>","DOI":"10.1002\/ar.24586","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T16:41:21Z","timestamp":1611333681000},"page":"1313-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Central nervous system development in rabbits (\n                    <scp>\n                      <i>Oryctolagus cuniculus<\/i>\n                    <\/scp>\n                    L. 1758)"],"prefix":"10.1002","volume":"304","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-5013","authenticated-orcid":false,"given":"Adriana Raquel","family":"de Almeida da 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