{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:23:03Z","timestamp":1769152983234,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Therapeutic hypothermia (TH) using servo\u2010controlled cooling devices has proved to be a safe and effective method to reduce mortality and sequelae in neonates with hypoxic\u2013ischemic encephalopathy (HIE). However, such cooling devices can be expensive and have limited availability in low\u2010 and middle\u2010income countries. To evaluate the feasibility and effectiveness of low\u2010cost cooling devices (ice packs) to reach and maintain the target temperature in newborns with moderate or severe HIE. Descriptive retrospective cross\u2010sectional study, including newborns with gestational age \u226535\u2009weeks, weight \u22651800\u2009g, with diagnosis of moderate or severe HIE, submitted to whole body hypothermia using ice packs for 72\u2009hr. Data was obtained from medical records and databases. The thermal curves of each patient, time spent at the target temperature and rewarming time were evaluated. Complications directly related to therapeutic hypothermia, evolution, and early outcomes before hospital discharge were analyzed. Seventy\u2010one newborns met the criteria for TH, and 61 completed the entire cooling period and were included in the final analysis. The average time to reach the target temperature was 1.50\u2009\u00b1\u20091.3\u00a0hr. The mean temperature during the cooling period was 33.5\u00b0C (\u00b10.62). 82.32% of the measurements were within the target temperature range (from 33 to 34\u00b0C). The following adverse events were observed during TH: pulmonary hypertension 11.3%, arrhythmia 4.2%, and coagulopathy 26.7%. Whole body hypothermia using low\u2010cost devices proved to be an effective method in the absence of availability of servo\u2010controlled devices, representing a plausible option in restricted resource settings.<\/jats:p>","DOI":"10.1002\/ar.24615","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T07:09:36Z","timestamp":1615964976000},"page":"1217-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of reaching and maintaining therapeutic hypothermia target temperature using low\u2010cost devices in newborns with hypoxic\u2013ischemic encephalopathy"],"prefix":"10.1002","volume":"304","author":[{"given":"Adriana Nishimoto","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Neonatal Division, Department of Pediatrics, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo  S\u00e3o Paulo 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Department of Pediatrics, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Roberto","family":"Pachi","sequence":"additional","affiliation":[{"name":"Neonatal Division, Department of Pediatrics, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Paulo Martins","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Neonatal Division, Department of Pediatrics, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo  S\u00e3o Paulo 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