{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:56Z","timestamp":1772118176011,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007231","name":"Cornell University","doi-asserted-by":"publisher","award":["NIH S10OD016191"],"award-info":[{"award-number":["NIH S10OD016191"]}],"id":[{"id":"10.13039\/100007231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Following the discovery of heart regeneration in zebrafish, several more species within the Cyprinidae family have been found to have the same capability, suggesting heart regeneration may be conserved within this family. Although gonad regeneration has been observed in grass carp (\n                    <jats:italic>Ctenopharyngodon idella<\/jats:italic>\n                    ), one of the largest cyprinid fish, the species' response to cardiac injury has not been characterized. Surprisingly, we found cardiomyocytes do not repopulate the injured region following cryoinjury to the ventricle, instead exhibiting unresolved fibrosis and decreased cardiac function that persists for the 8\u2010week duration of this study. Additionally, fibroblasts are likely depleted following injury, a phenomenon not previously described in any cardiac model. The data collected in this study indicate that heart regeneration is unlikely in grass carp (\n                    <jats:italic>C. idella<\/jats:italic>\n                    ). It is possible that not all members of the Cyprinidae family possesses regenerative capability observed in zebrafish. Further study of these phenomenon may reveal the underlying differences between regeneration versus unresolved fibrosis in heart disease.\n                  <\/jats:p>","DOI":"10.1002\/ar.24706","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T01:50:03Z","timestamp":1625449803000},"page":"66-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Persistent fibrosis and decreased cardiac function following cardiac injury in the\n                    <scp>\n                      <i>Ctenopharyngodon idella<\/i>\n                    <\/scp>\n                    (grass carp)"],"prefix":"10.1002","volume":"305","author":[{"given":"Daniel W","family":"Long","sequence":"first","affiliation":[{"name":"Meinig School of Biomedical Engineering Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"Charles H","family":"Webb","sequence":"additional","affiliation":[{"name":"Meinig School of Biomedical Engineering Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-382X","authenticated-orcid":false,"given":"Yadong","family":"Wang","sequence":"additional","affiliation":[{"name":"Meinig School of Biomedical Engineering Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"issue":"2","key":"e_1_2_7_3_1","first-page":"79","article-title":"Functional and structural regeneration in the axolotl heart (Ambystoma mexicanum) after partial ventricular amputation","volume":"80","author":"Cano\u2010Mart\u00ednez A.","year":"2010","journal-title":"Archivos de Cardiologia de Mexico"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-11-21"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.12.018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013287"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-002-0249-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu025"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-017-0027-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-010-9400-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.060897"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2014.02.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24154"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-16-1003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08899"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21492"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25605"},{"key":"e_1_2_7_18_1","volume-title":"Hydra and the birth of experimental biology, 1744: Abraham Trembley's memoires concerning the polyps","author":"Lenhoff S. 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