{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:13:00Z","timestamp":1775063580883,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since the fissula ante fenestram (FAF) is considered as a focus of otosclerotic lesion and a route of perilymph leakage, there are few description of prenatal development of the cartilaginous canal passing though the cochlear wall. We examined the sagittal and frontal histological sections of the ear from 32 human fetuses at 8\u201337\u2009weeks of gestational age. At 8\u201312\u2009weeks, in the immediately anterior side of a connection between the cochlear and canalicular parts of the otic capsule cartilage, the FAF appeared as a tear of a cartilage between the basal and second turns of the cochlea. The tear became a slit opening to the scala vestibuli. At 13\u201315\u2009weeks, the FAF, less than 1.2\u2009mm in length, had the anterosuperior and postero\u2010inferior apertures: the former was near the geniculate ganglion and became closed after 15\u2009weeks, while the latter approached the oval window. Third trimester fetuses, the FAF, 1.5\u20132.0\u2009mm in length, consistently carried a single, postero\u2010inferior aperture extending along the anterior margin of the oval window and it contained no definite epithelium and vessel. Although it was endochondral ossification, there was no clear zonation in cartilage cells of the FAF. A mechanical stress during three\u2010dimensional coiling of the cochlear ducts seemed to provide the FAF. After the FAF was established, the stapes footplate might use a part of the inferior aperture for the syndesmosis. A specific ossification was seen in the FAF, but it might rarely cause the pathological syndesmosis.<\/jats:p>","DOI":"10.1002\/ar.24711","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T06:19:49Z","timestamp":1625811589000},"page":"424-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fetal development and growth of the fissula ante fenestram in the human ear"],"prefix":"10.1002","volume":"305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5423-4492","authenticated-orcid":false,"given":"Jos\u00e9 Francisco","family":"Rodr\u00edguez\u2010V\u00e1zquez","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology School of Medicine, Complutense University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Cruz","family":"Iglesias\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Cl\u00ednico San Carlos, Complutense University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Poch","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Cl\u00ednico San Carlos, Complutense University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Murakami","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Jikou\u2010kai Clinic of Home Visits  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Akita University School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Honkura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"369","volume-title":"Surgical anatomy of the temporal bone and ear","author":"Anson B. 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