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A series of linear measurements, areas and volumes were extracted from a collection of 227 medical CT\u2010scans of children from 0 to 6\u2009years of age. These measurements describe aspects of the form of the orbit, maxilla, peri\u2010alveolar (subnasal) region, nasal area, eye, oral region, masseter, and temporal muscles. Hypothesized interactions were then examined using path analysis. Two paths were designed: the first to investigate potential interactions in, and relative contributions of the nasal derivatives and adjacent regions to overall facial growth and development; the second path sees the addition of facial soft tissue measurements and aims to assess their effects on skeletal components, and on overall facial growth and development. The results of the first path indicate a large contribution of the nasal and subnasal regions to facial development. This indicates that the nasal septum and the developing dentition provide an important but variable contribution to facial ontogeny during early years. This result is confirmed in the second path, where the soft tissue elements were added to the diagram. Results of the second path indicate that the soft tissues contribute only locally to the development of some skeletal elements of the face. This indicates that the contribution of skeletal components has a more direct effect on facial height than soft tissue matrices, however there are complex interactions between soft tissues and skeletal elements throughout ontogeny.<\/jats:p>","DOI":"10.1002\/ar.24719","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T09:23:35Z","timestamp":1626773015000},"page":"1892-1909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The role of the nasal region in craniofacial growth: An investigation using path analysis"],"prefix":"10.1002","volume":"305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4729-3651","authenticated-orcid":false,"given":"Federica","family":"Landi","sequence":"first","affiliation":[{"name":"Institute of Medical and Biomedical Education St. George's University  London UK"},{"name":"Hull York Medical School University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Barraclough","sequence":"additional","affiliation":[{"name":"Hull York Medical School University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6254-1203","authenticated-orcid":false,"given":"Andrej","family":"Evteev","sequence":"additional","affiliation":[{"name":"Anuchin's Research Institute and Museum of Anthropology Lomonosov Moscow State University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoliy","family":"Anikin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Scientific Center of Children Health  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Satanin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Burdenko Scientific Research Institute of Neurosurgery  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-0809","authenticated-orcid":false,"given":"Paul","family":"O'Higgins","sequence":"additional","affiliation":[{"name":"Hull York Medical School University of York  York UK"},{"name":"Department of Archaeology University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ar.10119","article-title":"Common patterns of facial ontogeny in the hominid lineage","volume":"269","author":"Ackermann R. 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