{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:32:01Z","timestamp":1781083921734,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone diseases are commonly found in the fossil record, especially in mammals of the Pleistocene megafauna, which exhibit signs of overload in the articulations. However, pathologies that affect soft tissues are not usually reported, even due to the nature of fossilization that rarely preserves such materials. In paleoneurological research using CT scan and three\u2010dimensional reconstructions of Pleistocene sloths, an anomaly is discovered in the space that houses the pituitary gland, the <jats:italic>sella turcica<\/jats:italic>. The tomographic analysis of a <jats:italic>Valgipes bucklandi<\/jats:italic> skull revealed a great enlargement at the <jats:italic>sella turcica<\/jats:italic>, at the medial region in the body of the basisphenoid bone. The images delimit an enlarged dorsal\u2013ventral projection, measuring approximately 15\u2009mm height, at the tridimensional reconstructed endocranium. Taphonomic processes, such as the action of necrophagous agents, were discarded due to the shape and conditions of the structure, which also showed signs of bone remodeling. Thus, it is possible to affirm that a paleopathological process altered the size of the pituitary gland of the specimen MCT 3993\u2010M, being probably a pituitary tumor.<\/jats:p>","DOI":"10.1002\/ar.24786","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T12:08:15Z","timestamp":1633003695000},"page":"1394-1401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The first evidence of pituitary gland tumor in ground sloth <i>Valgipes bucklandi<\/i> Lund, 1839"],"prefix":"10.1002","volume":"305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-5297","authenticated-orcid":false,"given":"Roberta Veronese","family":"do Amaral","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Paleovertebrados, Departamento de Geologia e Paleontologia Universidade Federal do Rio de Janeiro, Museu Nacional  Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Laborat\u00f3rio de Processamento de Imagem Digital \u2013 LAPID, Museu Nacional Universidade Federal do Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Barbosa De","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Paleovertebrados, Departamento de Geologia e Paleontologia Universidade Federal do Rio de Janeiro, Museu Nacional  Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Laborat\u00f3rio de Processamento de Imagem Digital \u2013 LAPID, Museu Nacional Universidade Federal do Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Alex Kugland De","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Paleovertebrados, Departamento de Geologia e Paleontologia Universidade Federal do Rio de Janeiro, Museu Nacional  Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Laborat\u00f3rio de Processamento de Imagem Digital \u2013 LAPID, Museu Nacional Universidade Federal do Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1108-4188","authenticated-orcid":false,"given":"Rafael","family":"Delcourt","sequence":"additional","affiliation":[{"name":"Instituto de Geoci\u00eancias, Universidade Estadual de Campinas, Universidade Estadual de Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5603\/MRJ.2018.0016"},{"key":"e_1_2_10_3_1","first-page":"1","volume-title":"Tecnologias 3D: paleontologia, arqueologia, fetologia","author":"Azevedo S. 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