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Its composite architecture and central location amidst the nasal cavity, pharyngotympanic tube, palate, and skull base bears implications for basic physiologic functions including breathing, vocalization, and alimentation. Over the course of evolution, morphological modifications of nasopharyngeal anatomy have occurred in genus Homo which serve to distinguish the human upper aerodigestive tract from that of other mammals. Understanding of these adaptive changes from both a comparative anatomy and clinical perspective offers insight into the unique blueprint which underpins many clinical pathologies currently encountered by anthropologists, scientists, and otorhinolaryngologists alike. This discussion intends to familiarize readers with the fundamental role that nasopharyngeal morphology plays in upper aerodigestive tract conditions, with consideration of its newfound clinical relevance in the era of the COVID\u201019 pandemic.<\/jats:p>","DOI":"10.1002\/ar.24926","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T22:59:09Z","timestamp":1649285949000},"page":"2065-2074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical perspectives on nasopharyngeal morphology in humans"],"prefix":"10.1002","volume":"305","author":[{"given":"Rebecca","family":"Rohde","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7653-1508","authenticated-orcid":false,"given":"David R.","family":"Friedland","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/02-049.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.08.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.1293"},{"issue":"8","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/ar.24790","article-title":"Three\u2010dimensional form and function of the nasal cavity and nasopharynx in humans and chimpanzees","volume":"305","author":"Bastir M.","year":"2021","journal-title":"The Anatomical Record"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700116"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.029983"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199604000-00002"},{"key":"e_1_2_7_9_1","first-page":"1253","volume-title":"Head and neck surgery: otolaryngology","author":"Bluestone C. 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