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In this study, we determined sperm motility and the activities of antioxidant enzymes and oxidation products in the testis of rats with ornidazole (ORN)\u2010induced asthenozoospermia and further examined and compared the differential effects of moxa smoke (MS) and cigarette smoke (CS) on sperm motility and oxidative stress (OS) of asthenozoospermic rats. The smoke intervention was initiated 11\u2009days after intragastric administration of ORN, followed by the examination of testis index, sperm parameters, OS\u2010related gene levels, and testicular histopathology. Sperm motility and antioxidant enzyme activities, as well as oxidation products significantly decreased in ORN\u2010induced rats compared with MS\u2010treated rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05\u2013.001). MS treatment restored the reduced sperm motility and activities of glutathione peroxidase, superoxide dismutase, and catalase, but increased the malondialdehyde and nitric oxide synthetase levels in ORN\u2010induced rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05\u2013.001). Also, the histopathological changes in the testis of ORN\u2010induced rats were improved by MS treatment. The study highlighted that MS was an effective factor in moxibustion therapy, which notably improved the sperm motility of asthenozoospermic rats by inhibiting OS in the reproductive system.<\/jats:p>","DOI":"10.1002\/ar.25002","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T08:48:15Z","timestamp":1654505295000},"page":"3021-3032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of moxa smoke on sperm parameters and oxidative stress in rats with asthenozoospermia"],"prefix":"10.1002","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-6075","authenticated-orcid":false,"given":"Yajie","family":"Liu","sequence":"first","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"An","sequence":"additional","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guogang","family":"Xing","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute Peking University  Beijing China"},{"name":"Department of Neurobiology School of Basic Medical Sciences and Neuroscience Research Institute, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirun","family":"Jin","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute Peking University  Beijing China"},{"name":"Department of Neurobiology School of Basic Medical Sciences and Neuroscience Research Institute, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute Peking University  Beijing China"},{"name":"Department of Neurobiology School of Basic Medical Sciences and Neuroscience Research Institute, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwei","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center  Xi'an China"},{"name":"Research Center of Reproductive Medicine, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"He","sequence":"additional","affiliation":[{"name":"School of Life Science Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"The Sixth Medical Center General Hospital of People's Liberation Army  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiali","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Han","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baixiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.02.111"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-016-0207-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222313164"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/reprod\/118.1.127"},{"key":"e_1_2_10_6_1","first-page":"805","article-title":"Effects of passive smoking on reproductive capacity of male mice","volume":"34","author":"Chen X. 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