{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:51:33Z","timestamp":1759971093790,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI \/ 16K08454"],"award-info":[{"award-number":["KAKENHI \/ 16K08454"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell migration from the olfactory placode (OP) is a well\u2010known phenomenon wherein various cell types, such as gonadotropin\u2010releasing hormone (GnRH)\u2010producing neurons, migrate toward the telencephalon (TEL) during early embryonic development. However, the spatial relationship between early migratory cells and the forebrain is unclear. We examined the early development of whole\u2010mount chick embryos to observe the three\u2010dimensional spatial relationship among OP\u2010derived migratory neurons, olfactory nerve (ON), and TEL. Migratory neurons that express highly polysialylated neural cell adhesion molecule (PSA\u2010NCAM) emerge from the OP and spread over a relatively wide TEL area at the Hamburger and Hamilton (HH) stage 17. Most migratory neurons form a cellular cord between the olfactory pit and rostral TEL within HH18\u201320. The earliest axons from the olfactory epithelium (OE) were detected along this neuronal cord using DiI\u2010labeling at HH21. Furthermore, a few PSA\u2010NCAM\u2010positive neurons were dispersed around the cellular cord and over the lateral TEL at HH18. A long cellular cord branch extending to the lateral TEL was transiently observed within HH18\u201324. These results suggest a novel migratory route of OP\u2010derived neurons during the early developmental stages. Following GFP vector introduction into the OP of HH13\u201315 embryos, labeled neurons were detected around and within the lateral TEL at HH23 and HH27. At HH36, labeled cells were observed in the rostral\u2010lateral TEL, including the olfactory bulb (OB) region. GFP\u2010labeled and calretinin\u2010positive neurons were detected in the OB, suggesting that early OP\u2010derived neurons enter the forebrain and function as interneurons in the OB.<\/jats:p>","DOI":"10.1002\/ar.25080","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T01:15:51Z","timestamp":1663204551000},"page":"298-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Wide\u2010ranging migration and destination of early olfactory placode\u2010derived neurons in chick embryos"],"prefix":"10.1002","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-5391","authenticated-orcid":false,"given":"Momoko","family":"Miyakawa","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Neuropathology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Cell Biology and Neuroscience Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuko","family":"Murakmai","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Neuropathology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9104-533X","authenticated-orcid":false,"given":"Yasuo","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Neuropathology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1726"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2021.718221"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.139444"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00199-S"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199904)214:4<349::AID-AJA7>3.0.CO;2-E"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.7.1059"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00334-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.07.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21966"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017379"},{"key":"e_1_2_9_14_1","first-page":"47","article-title":"Cell migration from the chick olfactory placode: a light and electron microscopic study","volume":"69","author":"Mendoza A. S.","year":"1982","journal-title":"Journal of Embryology and Experimental Morphology"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22497"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.14.489"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.1.6425"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(91)90073-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(94)90169-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2019.09.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13064-017-0090-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970414)380:3<293::AID-CNE1>3.0.CO;2-Y"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0486-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10041-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.01.043"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/338161a0"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(09)80003-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(93)90111-3"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.12.367"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2001.00685.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.060244"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(93)90173-8"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.03.005"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.20.8132"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2010.02034.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12007"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.25080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ar.25080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.25080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:33:31Z","timestamp":1759926811000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.25080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,22]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/ar.25080"],"URL":"https:\/\/doi.org\/10.1002\/ar.25080","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"type":"print","value":"1932-8486"},{"type":"electronic","value":"1932-8494"}],"subject":[],"published":{"date-parts":[[2022,9,22]]},"assertion":[{"value":"2022-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}