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This study aims to explore the optimum parameter of electroacupuncture (EA) stimulation in regulating the sympathoadrenal medullary pathway and evaluate EA's anti\u2010inflammatory effect on sepsis. To determine the optimum parameter of EA at homotopic acupoint on adrenal sympathetic activity, the left adrenal sympathetic nerve firing rate evoked by different intensities of single shock electrical stimulation (ES) at ST25 in healthy male Sprague\u2013Dawley rats were evaluated by in vivo electrophysiological recording, and the levels of norepinephrine (NE) and its metabolites normetanephrine (NMN) were also examined using mass spectrometry. To verify the role of EA at ST25 in sepsis, the rats were given an intraperitoneal injection of lipopolysaccharide (LPS) to induce sepsis model, and survival rate, clinical score, and the level of interleukin (IL)\u20106, IL\u20101\u03b2, and IL\u201010 were evaluated after EA application. We observed that 3\u00a0mA is the optimal intensity for activating adrenal sympathetic nerve, which significantly elevated the level of NE in the peripheral blood. For LPS\u2010treated rats, EA at the ST25 apparently increased the survival rate and improved the clinical score compared to the control group. Furthermore, 3\u00a0mA EA at ST25 significantly decreased pro\u2010inflammatory cytokines IL\u20106 and IL\u20101\u03b2 and upregulated anti\u2010inflammatory cytokine IL\u201010 compared to the LPS\u2010treated group. Overall, our data suggested that 3\u00a0mA is the optimal EA intensity at ST25 to activate the sympathoadrenal medullary pathway and exert an anti\u2010inflammatory effect in sepsis.<\/jats:p>","DOI":"10.1002\/ar.25102","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T06:38:33Z","timestamp":1666852713000},"page":"3178-3188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Adrenal sympathetic nerve mediated the anti\u2010inflammatory effect of electroacupuncture at\n                    <scp>ST25<\/scp>\n                    acupoint in a rat model of sepsis"],"prefix":"10.1002","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-5780","authenticated-orcid":false,"given":"Ziyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences  Beijing 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