{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:51:41Z","timestamp":1768884701485,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471169"],"award-info":[{"award-number":["81471169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early brain injury (EBI) refers to a series of pathophysiological brain lesions that occur within 72\u2009hr after subarachnoid hemorrhage (SAH), which is an extremely crucial factor in the poor prognosis of patients. In EBI, ferroptosis has been proven to cause neuronal death. Quercetin (QCT) is effective in deactivating reactive oxygen species (ROS), inhibiting lipid peroxidation, and even chelating iron, but its role in SAH remains unclear. In this study, the mortality rate, severity grade of SAH, brain water content (BWC), blood\u2013brain barrier permeability, and neurological function of the rats were detected. Moreover, mitochondrial morphology in cortical neurons were observed and their sizes were subsequently quantified. The levels of lipid peroxidation on glutathione and malondialdehyde (MDA) and glutathione peroxidase (GSH\u2010Px) were determined, whereas the protein expressions of glutathione peroxidase 4 (GPX4), SLC7A11 (xCT), transferrin receptor 1 (TfR1), and ferroportin\u20101 (FPN1) were analyzed by western immunoblotting. The neurodegeneration involved in EBI was investigated by fluoro\u2010Jade C staining, while iron staining was utilized to measure iron content. Our results showed that inhibition of ferroptosis by QCT could suppress EBI and improve neurological function in SAH rats. QCT increased the expression levels of GPX4, xCT, and FPN1, while downregulated TfR1, and exerted protective effects on neurons as well as alleviated iron accumulation and lipid peroxidation in the cortex of SAH rats. In conclusion, our study revealed that QCT might alleviate the EBI by inhibiting ferroptosis in SAH rats.<\/jats:p>","DOI":"10.1002\/ar.25130","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T02:27:52Z","timestamp":1669602472000},"page":"638-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Quercetin alleviates subarachnoid hemorrhage\u2010induced early brain injury via inhibiting ferroptosis in the rat model"],"prefix":"10.1002","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7567-5665","authenticated-orcid":false,"given":"Dian","family":"Jiao","sequence":"first","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmiao","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjian","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Fourth Affiliated Hospital, Zhejiang University School of Medicine  Yiwu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengtao","family":"Ni","sequence":"additional","affiliation":[{"name":"Graduate School Bengbu Medical College  Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghong","family":"Shen","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Hangzhou Medical College Hangzhou Medical College  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-4347","authenticated-orcid":false,"given":"Marong","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-3308","authenticated-orcid":false,"given":"Xiangyang","family":"Gong","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center, Department of Radiology Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.11.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.031905.164337"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0506-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.848529"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.09.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009229429250"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2095-2_10"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1416"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.7634"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132814Y.0000000437"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.11.2405"},{"key":"e_1_2_10_14_1","first-page":"124","article-title":"The physiological functions of iron regulatory proteins in iron homeostasis \u2010 An update","volume":"5","author":"Ezhang D. L.","year":"2014","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170406142631"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3064"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5671"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.4.627"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.01.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064341"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2154"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01745-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2007.10.005"},{"key":"e_1_2_10_24_1","first-page":"1","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li J.","year":"2020","journal-title":"Cell Death & Disease"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164237"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00850-1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-140446"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30668-7"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496922"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.12.013"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.05.009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2015.10.002"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.08.004"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113692"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.01.005"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.685364"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.07.007"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0461-9"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172885"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13069"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00840-x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05859"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2021.1949302"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.245480"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00611"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-014-1457-1"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.25130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ar.25130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.25130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:53:32Z","timestamp":1759928012000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.25130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/ar.25130"],"URL":"https:\/\/doi.org\/10.1002\/ar.25130","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"value":"1932-8486","type":"print"},{"value":"1932-8494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"assertion":[{"value":"2022-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}