{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:56:04Z","timestamp":1772517364608,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent report suggested that LIM homeobox 6 (Lhx6)\u2009+\u2009GABA\u2010releasing neurons of the ventral zona incerta (VZI) promote sleep, particularly paradoxical sleep (PS). While their potential involvement in sleep still needs to be firmly confirmed, little is known about their specific input\/output connections with widespread brain regions, including those involved in sleep. Thus, the present study was designed to examine whether Lhx6\u2010expressing neurons (in parallel to intermingled MCH\u2010expressing ones) may send efferent projections to cholinergic and\/or monoaminergic nuclei from basal forebrain (BF) to brainstem (BS). Based on the present observations, the proportions of Lhx6+ neuronal projection to the BF and BS cholinergic nuclei over the total number of Lhx6+ VZI cells were approximately 5.9% and 6.9%, respectively. Likewise, the proportions of Lhx6+ neuronal projection to the dorsal raphe and locus coeruleus over the total number of Lhx6+ VZI cells were about 4.3% and 3.9%, respectively. In addition, Lhx6+ cells projecting to the cholinergic or monoaminergic nuclei were scattered along the entire dorsal\u2010to\u2010ventral extent of the VZI. Based on the present as well as our previous observations, it is suggested that Lhx6+ VZI neurons might play an important role in the regulation of PS, partly via the neural network involving the cholinergic as well as monoaminergic nuclei of the rat.<\/jats:p>","DOI":"10.1002\/ar.25143","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T06:33:41Z","timestamp":1672382021000},"page":"905-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Projections from <scp>LIM<\/scp> homeobox 6 (Lhx6)\u2009+\u2009zona incerta neurons to the cholinergic or monoaminergic nuclei of the rat"],"prefix":"10.1002","volume":"306","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-4862","authenticated-orcid":false,"given":"Sung\u2010Gyoon","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine Konkuk University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-5907","authenticated-orcid":false,"given":"Eun\u2010Yeup","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine Konkuk University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3273-8336","authenticated-orcid":false,"given":"Hyun\u2010Sook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine Konkuk University  Seoul South Korea"},{"name":"Research Institute of Medical Science, School of Medicine Konkuk University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4662-14.2015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5339-03.2004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2617-13.2014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5502-08.2009"},{"issue":"185","key":"e_1_2_8_6_1","first-page":"1","article-title":"Anatomical organization of MCH connections with the pallidum and dorsal striatum in the rat","volume":"8","author":"Chometton S.","year":"2014","journal-title":"Frontiers in Systems Neuroscience"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1885-12.2012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2007.10.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02041873"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1259-09.2009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21201"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00008.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.09.051"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3522"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24407"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0444-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1225-13.2013"},{"issue":"244","key":"e_1_2_8_18_1","first-page":"1","article-title":"Neurons containing orexin or melanin concentrating hormone reciprocally regulate wake and sleep","volume":"8","author":"Konadhode R. 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