{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:04Z","timestamp":1786977064807,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inflammatory injury following ischemia\u2010reperfusion (I\/R) severely limits the efficacy of stroke treatment. Edaravone dexborneol (C.EDA) has been shown to reduce inflammation following a cerebral hemorrhage. However, the precise anti\u2010inflammatory mechanism of C.EDA is unknown. In this study, we investigated whether C.EDA provides neuroprotection after I\/R in rats, as well as the potential mechanisms involved. A middle cerebral artery occlusion\/reperfusion (I\/R) model was created using Sprague\u2010Dawley rats. The blood flow of the central cerebral artery was monitored by a laser speckle imaging system. The neurological score was used to assess behavioral improvement. Cerebral infarction volume was measured by TTC staining. And the integrity of the blood\u2013brain barrier was detected by Evan's blue staining. The expression of the nuclear factor kappa\u2010B (NF\u2010\u03baB)\/ the NOD\u2010like receptor protein (NLRP3) inflammasome signal pathway and microglia polarization were detected by immunofluorescence and Western blotting. The cerebral blood flow ratio indicates that the cerebral I\/R model was successfully established. After reperfusion for 72 h, the improvement of neurological scores, infarct volume reduction, and integrity of the blood\u2013brain barrier was observed in I\/R rats with C.EDA treatment. Meanwhile, the immunofluorescence result showed that the expression of iNOS, NLRP3, and NF\u2010\u03baB protein was decreased and the level of Arg1 was increased. Western blot analysis showed that the expression of NF\u2010\u03baB\/NLRP3 signal pathway\u2010related protein was decreased. In conclusion, this study indicates that C.EDA alleviates I\/R injury by blocking the activation of the NLRP3 inflammasome and regulating the polarization of M1\/M2 microglia via the NF\u2010\u03baB signal pathway.<\/jats:p>","DOI":"10.1002\/ar.25296","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:40:37Z","timestamp":1689900037000},"page":"372-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Edaravone dexborneol alleviates cerebral ischemia\u2010reperfusion injury through\n                    <scp>NF\u2010\u03baB<\/scp>\n                    \/\n                    <scp>NLRP3<\/scp>\n                    signal pathway"],"prefix":"10.1002","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9920-776X","authenticated-orcid":false,"given":"Guanghong","family":"Shen","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences and Forensic 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Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of System Medicine Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7567-5665","authenticated-orcid":false,"given":"Dian","family":"Jiao","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-4347","authenticated-orcid":false,"given":"Marong","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of System Medicine Zhejiang University School of Medicine  Hangzhou China"},{"name":"Children's Hospital of Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou 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