{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T04:21:55Z","timestamp":1778991715715,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017787","name":"Health Science Center, University of North Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007114","name":"Ralph W. and Grace M. Showalter Research Trust Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteogenesis imperfecta (OI) is known to cause hearing loss in ~60% of the affected human population. While OI\u2010related pathologies have been studied in the middle ear, the development of cochlear pathologies is less well understood. In this study, we examine OI\u2010related pathologies of the cochlea in a mouse model of OI to (1) document variation between OI and unaffected mice, and (2) assess the intrusion of the otic capsule onto the cochlea by analyzing differences in duct volumes. Juvenile and adult OIM C57BL\/6mice were compared to unaffected wildtype (WT) mice using three\u2010dimensional models of the cochlea generated from high resolution micro\u2010CT scans. Two\u2010tailed Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests were then used to investigate duct volume differences both within and between the OI and WT samples. Areas of higher ossification were observed at the cochlear base in the OI sample. OI mice also had significant intraindividual differences in duct volume between right and left ears (4%\u201315%), an effect not observed in WT mice. WT and OI duct volumes showed a large degree of overlap, although the OIM volumes were more variable. Our findings indicate that OIM mice are likely to exhibit more asymmetry and variation in cochlear volume despite minor differences in sample cochlear volumes, possibly due to bony capsule intrusion. This suggests a potential mechanism of hearing loss, and a high potential for cochlear and otic capsule alteration in OIM mice.<\/jats:p>","DOI":"10.1002\/ar.25298","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T10:15:16Z","timestamp":1690625716000},"page":"592-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Morphological variability in the inner ear of mice with osteogenesis imperfecta"],"prefix":"10.1002","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1097-3414","authenticated-orcid":false,"given":"Lila A.","family":"Huston","sequence":"first","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"University of the Incarnate Word School of Medicine  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tooba S.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Arkansas College of Osteopathic Medicine  Chad Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3522-033X","authenticated-orcid":false,"given":"Jacob C.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Edward Via College of Osteopathic Medicine  Monroe Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-0271","authenticated-orcid":false,"given":"Jason M.","family":"Organ","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology &amp; Physiology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-7873","authenticated-orcid":false,"given":"Rachel A.","family":"Menegaz","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma K.","family":"Handler","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren A.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2019.05.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2021.107708"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2010.06.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20071"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-016-0539-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000715R"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/983942"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31826bf19b"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320400032030"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2020.34.s1.09473"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22408"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872020001201781"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.25298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:31:59Z","timestamp":1759951919000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.25298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,29]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ar.25298"],"URL":"https:\/\/doi.org\/10.1002\/ar.25298","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"value":"1932-8486","type":"print"},{"value":"1932-8494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,29]]},"assertion":[{"value":"2023-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}