{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:11:39Z","timestamp":1759954299493,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017787","name":"Health Science Center, University of North Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteogenesis imperfecta (OI), a disorder of type I collagen, causes skeletal deformities as well as defects in dental tissues, which lead to increased enamel wear and smaller teeth with shorter roots. Mice with OI exhibit similar microstructural dentin changes, including reduced dentin tubule density and dentin cross\u2010sectional area. However, the effects of these mutations on gross dental morphology and dental tissue volumes have never been characterized in the osteogenesis imperfecta murine (OIM) mouse model. Here we compare mineralized dental tissue measurements of OIM mice and unaffected wild type (WT) littermates at the juvenile and adult stages. The maxillary and mandibular incisors and first molars were isolated from microCT scans, and tissue volumes and root length were measured. OIM mice have smaller teeth with shorter roots relative to WT controls. Maxillary incisor volumes differed significantly between OIM and WT mice at both the juvenile and young adult stage, perhaps due to shortening of the maxilla itself in OIM mice. Additionally, adult OIM mice have significantly less crown enamel volume than do juveniles, potentially due to loss through wear. Thus, OIM mice demonstrate a dental phenotype similar to humans with OI, with decreased tooth size, decreased root length, and accelerated enamel wear. Further investigation of dental development in the OIM mouse may have important implications for the development and treatment of dental issues in OI patients.<\/jats:p>","DOI":"10.1002\/ar.25306","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:34:43Z","timestamp":1693197283000},"page":"600-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dental tissue changes in juvenile and adult mice with osteogenesis imperfecta"],"prefix":"10.1002","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3522-033X","authenticated-orcid":false,"given":"Jacob C.","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Edward Via College of Osteopathic Medicine  Monroe Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tooba S.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Arkansas College of Osteopathic Medicine  Fort Smith Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1097-3414","authenticated-orcid":false,"given":"Lila A.","family":"Huston","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"University of the Incarnate Word School of Osteopathic Medicine  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley T.","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-0271","authenticated-orcid":false,"given":"Jason M.","family":"Organ","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology &amp; Physiology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren A.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-7873","authenticated-orcid":false,"given":"Rachel A.","family":"Menegaz","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma K.","family":"Handler","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200290001005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-7657-3_19"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18512-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.03.004"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"115","article-title":"Dental findings in osteogenesis imperfecta: I. 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