{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:25:02Z","timestamp":1790105102588,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017787","name":"Health Science Center, University of North Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007114","name":"Ralph W. and Grace M. 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Virtual endocast models were used to measure brain volume, and 3D landmarks were collected from the cranium and brain endocasts. Geometric morphometric analyses were used to compare brain shape and integration between the genotypes. OIM mice had increased brain volumes (relative to cranial centroid size) only at the juvenile stage. No significant difference was seen in cranial base angle (CBA) between OIM and WT mice. However, CBA was higher in juvenile than in adult OIM mice. Brain shape was significantly different between OIM and WT mice at both stages, with OIM mice having more globular brains than WT mice. Neurocranial and brain morphology were strongly integrated within both genotypes, while adult OIM mice tended to have lower levels of skull\u2010brain integration than WT mice. These results suggest that neurocranial dysmorphologies in OI may be more severe at earlier stages of postnatal development. Decreased skull\u2010brain integration in adult mice suggests that compensatory mechanisms may exist during postnatal growth to maintain neurological function despite significant changes in neurocranial morphology.<\/jats:p>","DOI":"10.1002\/ar.25307","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:55:22Z","timestamp":1693198522000},"page":"581-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neurocranial growth in the <scp>OIM<\/scp> mouse model of osteogenesis imperfecta"],"prefix":"10.1002","volume":"307","author":[{"given":"Tooba S.","family":"Husain","sequence":"first","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Arkansas College of Osteopathic Medicine  Fort Smith Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3522-033X","authenticated-orcid":false,"given":"Jacob C.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Edward Via College of Osteopathic Medicine  Monroe Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1097-3414","authenticated-orcid":false,"given":"Lila A.","family":"Huston","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"University of the Incarnate Word School of Osteopathic Medicine  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-4290","authenticated-orcid":false,"given":"Courtney A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-8165","authenticated-orcid":false,"given":"Ashley T.","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3304-0634","authenticated-orcid":false,"given":"Lauren A.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-8088","authenticated-orcid":false,"given":"Emma K.","family":"Handler","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Anatomy and Cell Biology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-0271","authenticated-orcid":false,"given":"Jason M.","family":"Organ","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology &amp; Physiology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-7873","authenticated-orcid":false,"given":"Rachel A.","family":"Menegaz","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Adams D. 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