{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:07:26Z","timestamp":1790878046942,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07772"],"award-info":[{"award-number":["21K07772"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K14976"],"award-info":[{"award-number":["23K14976"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the fetal period, oxygenated blood from the placenta flows through the umbilical vein (UV), portal sinus, ductus venosus (DV), and inferior vena cava (IVC) to the heart. This venous route varies regionally in many aspects. Herein, we sought to characterize the venous route's morphological features and regional differences during embryonic and early\u2010fetal periods. Twenty\u2010nine specimens were selected for high\u2010resolution digitized imaging; 18 embryos were chosen for histological analysis. The venous route showed a primitive, large, S\u2010shaped curved morphology with regional narrowing and dilation at Carnegie stage (CS) 15. Regional differences in vessel\u2010wall differentiation became apparent from approximately CS20. The vessel wall was poorly developed in most DV parts; local vessel\u2010wall thickness at the inlet was first detected at CS20. The lumen of the venous route changed from a nonuniform shape to a relatively round and uniform morphology after CS21. During the early\u2010fetal period, two large bends were observed around the passage of the umbilical ring and at the inlet of the liver. The length ratio of the extrahepatic UV to the total venous route increased. The sectional area gradually increased during embryonic development, whereas differences in sectional area between the DV, UV, and IVC became more pronounced in the early\u2010fetal period. Furthermore, differences in the sectional area between the narrowest part of the DV and other hepatic veins and the transverse sinus became more pronounced. In summary, the present study described morphological, morphometric, and histological changes in the venous route throughout embryonic and early\u2010fetal development, clarifying regional characteristics.<\/jats:p>","DOI":"10.1002\/ar.25421","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T04:14:50Z","timestamp":1709957690000},"page":"3306-3326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Regional differences in the umbilical vein and ductus venosus at different stages of normal human development"],"prefix":"10.1002","volume":"307","author":[{"given":"Naoko","family":"Isotani","sequence":"first","affiliation":[{"name":"Human Health Science Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-0500","authenticated-orcid":false,"given":"Toru","family":"Kanahashi","sequence":"additional","affiliation":[{"name":"Human Health Science Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Informatics Kyoto University Graduate School of Informatics  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6925-6723","authenticated-orcid":false,"given":"Akio","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"SAGA Light Source  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-6927","authenticated-orcid":false,"given":"Shigehito","family":"Yamada","sequence":"additional","affiliation":[{"name":"Human Health Science Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Congenital Anomaly Research Center Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9660-9384","authenticated-orcid":false,"given":"Tetsuya","family":"Takakuwa","sequence":"additional","affiliation":[{"name":"Human Health Science Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,9]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"389","article-title":"The \u2018sphincter\u2019 of the ductus venosus","volume":"82","author":"Barron D. H.","year":"1942","journal-title":"The Anatomical Record"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2013.07.029"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091150203"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20679"},{"key":"e_1_2_11_6_1","article-title":"An interactive 92 three\u2010dimensional digital atlas and quantitative database of 93 human development","volume":"354","author":"de Bakker, B. S., de Jong, K. H., Hagoort, J., de Bree, K., Besselink, C. T., de Kanter, F. E. C., Veldhuis, T., Bais, B., 90 Schildmeijer, R., Ruijter, J. M., Oostra, R.\u2010J., 91 Christoffels, V. M., & Moorman, A. F. M.","year":"2016","journal-title":"Science"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"358","article-title":"The development of the ductus venosus in man and the goat","volume":"91","author":"Dickson A. 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