{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:12:19Z","timestamp":1779228739024,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac regeneration is a natural phenomenon that occurs in many species outside of humans. The goldfish (<jats:italic>Carassius auratus<\/jats:italic>) is an understudied model of cardiac wound response, despite its ubiquity as pets as well as its relationship to the better\u2010studied zebrafish. In this study, we examined the response of the goldfish heart to a resection injury. We found that by 70\u2009days post\u2010injury, goldfish scarlessly heal cardiac wounds under a certain size, with local cardiomyocyte proliferation driving the restoration of the myocardial layer. We also found the upregulation of extracellular matrix components related to cardiac regeneration in the injury site. This upregulation correlated with the level of cardiomyocyte proliferation occurring in the injury site, indicating an association between the two that warrants further exploration.<\/jats:p>","DOI":"10.1002\/ar.25549","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T06:34:09Z","timestamp":1722580449000},"page":"1378-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac regeneration in goldfish (<i>Carassius auratus<\/i>) associated with increased expression of key extracellular matrix molecules"],"prefix":"10.1002","volume":"308","author":[{"suffix":"IV","given":"Charles H.","family":"Webb","sequence":"first","affiliation":[{"name":"Meinig School of Biomedical Engineering, Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-382X","authenticated-orcid":false,"given":"Yadong","family":"Wang","sequence":"additional","affiliation":[{"name":"Meinig School of Biomedical Engineering, Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016955"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22978"},{"issue":"2","key":"e_1_2_9_4_1","first-page":"79","article-title":"Functional and structural regeneration in the axolotl heart (Ambystoma mexicanum) after partial ventricular amputation","volume":"80","author":"Cano\u2010Martinez A.","year":"2010","journal-title":"Archivos de Cardiolog\u00eda de M\u00e9xico"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.078543"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-11-21"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav0547"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.165753"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.12.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1389"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-002-0249-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-017-0027-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-010-9400-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.060897"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2014.02.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122665"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20121057"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08899"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08804"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21492"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-6029-8_13"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21892-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.08.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv190"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200708"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077857"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030345"},{"key":"e_1_2_9_28_1","first-page":"5","volume-title":"The freshwater fishes of Europe, volume 5\/III: Cyprinidae 2, part III: Carassius to Cyprinus, Gasterosteidae","author":"Szczerbowski J. 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