{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:31:54Z","timestamp":1792089114513,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study reexamined the immunolocalization of membranous serotonin transporter (SERT) in the rat carotid body, and demonstrated SERT\u2010immunoreactive cells of unreported morphology. SERT was immunohistochemically localized in a very small population of cell clusters or single type I cells (2.8%) immunoreactive for synaptophysin, the marker of these cells. Intense SERT immunoreactivity outlined the perinuclear cytoplasm and multiple cytoplasmic processes of type I cells. Of SERT\u2010immunoreactive type I cells, 14.6% and 32.6% were immunoreactive for tyrosine hydroxylase (TH) and dopamine beta\u2010hydroxylase, respectively, while 75.9% were immunoreactive for serotonin (5\u2010HT). 5\u2010HT\u2010immunoreactive products were localized in cell bodies rather than cytoplasmic processes. SERT\u2010immunoreactive type I cells were composed of an oval cell body with multiple threads and spherical or elongated cytoplasmic processes. Clusters or single SERT\u2010immunoreactive type I cells were localized between or attached to other TH\u2010immunoreactive type I cells by cell bodies or variform cytoplasmic processes. SERT\u2010immunoreactive type I cells mainly contained bassoon\u2010immunoreactive products in their cell bodies rather than their variform cytoplasmic processes. These results demonstrated the characteristic morphology of SERT\u2010immunoreactive type I cells, which extend multiple cytoplasmic processes with variform terminal parts. Their morphology might be suitable for uptake of 5\u2010HT to control the serotonergic modulation in the carotid body.<\/jats:p>","DOI":"10.1002\/ar.25575","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T07:29:03Z","timestamp":1727422143000},"page":"1504-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distribution and morphology of serotonin transporter\u2010immunoreactive type I cells in the rat carotid body"],"prefix":"10.1002","volume":"308","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-0623","authenticated-orcid":false,"given":"Takuya","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Anatomy and Cell Biology, Faculty of Agriculture Iwate University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9876-2692","authenticated-orcid":false,"given":"Sayed 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