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During early life, all mammals undergo the dynamic transition from suckling to mastication, a period coinciding with rapid cranial biomineralization. Osteogenesis imperfecta (OI), a genetic disorder that impacts the production of type I collagen, disrupts biomineralization, leading to craniofacial growth differences affecting quality of life. This study investigates craniofacial development during infant oral motor developmental stages in OI mice compared to unaffected wild\u2010type littermates (WT mice). We hypothesize OI mice will exhibit smaller overall size, and the adult OI phenotype will develop postnatally in response to masticatory loading. Point cloud and fixed landmarks were collected from micro\u2010computed tomography scans, then geometric morphometric analyses and interlandmark distances (ILDs) compared craniofacial size and shape between OI and WT mice at birth (P0;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200927 OI murine\/20 WT) and postnatal Days 7 (P7;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921\/21), 14 (P14;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916\/20), 21 (P21;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920\/26), and 28 (P28;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926\/33). This study found no size and shape differences between genotypes at birth. Starting at P7, OI mice are significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) smaller and display pronounced shape changes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) characterized by a larger neurocranium and a shorter viscerocranium. At P21, significant differences emerge in cranial base orientation, neurocranial width, viscerocranial shortening, and zygomatic arch displacement. These findings underscore the importance of early life oral motor stages in developing the adult OI craniofacial phenotype and oral health, suggesting earlier craniofacial interventions may improve effective treatment of OI.\n                  <\/jats:p>","DOI":"10.1002\/ar.25640","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T20:33:48Z","timestamp":1740515628000},"page":"3157-3174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early life functional transitions impact craniofacial morphology in osteogenesis imperfecta"],"prefix":"10.1002","volume":"308","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-4290","authenticated-orcid":false,"given":"Courtney A.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanusha","family":"Emanuel","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-7873","authenticated-orcid":false,"given":"Rachel A.","family":"Menegaz","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12035"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/11250000409356545"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1943\/1\/012095"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1555"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.11.PEDS14113"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-023-00823-5"},{"key":"e_1_2_9_8_1","first-page":"37","article-title":"A systems\u2010model for the morphological analysis of integration and modularity in human craniofacial evolution","volume":"86","author":"Bastir M.","year":"2008","journal-title":"Journal of Anthropological Sciences"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00644.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhevol.2010.03.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12059"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115061"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.13.110182.002315"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511573064"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345630420014301"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198305000-00005"},{"key":"e_1_2_9_17_1","first-page":"12","volume-title":"New vistas in orthodontics","author":"Carlson D. 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