{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:37:54Z","timestamp":1781217474341,"version":"3.54.1"},"reference-count":84,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Spermophilus xanthoprymnus<\/jats:italic>\n                    <\/jats:styled-content>\n                    during pre\u2010hibernation and hibernation periods using immunohistochemical staining. Synaptophysin expression, restricted to the inner plexiform layer (IPL) and outer plexiform layer (OPL) during pre\u2010hibernation, significantly increased in both layers during hibernation, with additional expression observed in the outer nuclear layer. NeuN immunoreactivity remained unchanged in the ganglion cell layer (GCL) but increased notably in the INL during hibernation. Calbindin\u2010D28k expression, prominent in the INL and plexiform layers during pre\u2010hibernation, decreased markedly in hibernation. In contrast, parvalbumin expression increased across all retinal layers, except the photoreceptor layer, during hibernation. Glial fibrillary acidic protein (GFAP) expression, observed in the NFL and GCL, was significantly reduced during hibernation. Iba\u20101 immunoreactivity, sparse in the IPL and OPL during pre\u2010hibernation, showed a pronounced increase in the IPL, OPL, and INL during hibernation periods. In conclusion, the expression of synaptophysin, NeuN, calbindin\u2010D28k, parvalbumin, GFAP, and Iba\u20101 was investigated for the first time in the retina of the Anatolian ground squirrel during pre\u2010hibernation and hibernation. This study reveals region\u2010specific shifts in retinal marker expression during pre\u2010hibernation and hibernation, providing a basis for future research into visual system adaptations and retinal plasticity under metabolic suppression.\n                  <\/jats:p>","DOI":"10.1002\/ar.25682","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T06:59:53Z","timestamp":1747378793000},"page":"451-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anatolian ground squirrel (\n                    <scp>\n                      <i>Spermophilus xanthoprymnus<\/i>\n                    <\/scp>\n                    ) retina: Comparative expression of synaptophysin,\n                    <scp>NeuN<\/scp>\n                    , calbindin\u2010D28k, parvalbumin,\n                    <scp>glial fibrillary acidic protein<\/scp>\n                    , and Iba\u20101 during pre\u2010hibernation and hibernation"],"prefix":"10.1002","volume":"309","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-5359","authenticated-orcid":false,"given":"Mehmet","family":"\u00d6zbek","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9365-4104","authenticated-orcid":false,"given":"Feyzullah","family":"Beyaz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Veterinary Medicine Erciyes University  Kayseri Turkey"},{"name":"Department of Neuroscience, Gevher Nesibe Genome and Stem Cell Institute Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-9280","authenticated-orcid":false,"given":"Mustafa","family":"\u00d6ztop","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Arts and Sciences Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1076-8625","authenticated-orcid":false,"given":"Harun","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-209X","authenticated-orcid":false,"given":"Ahmet","family":"Cabir","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Veterinary Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6571-2186","authenticated-orcid":false,"given":"Beg\u00fcm Fatma","family":"Kiryar","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Gevher Nesibe Genome and Stem Cell Institute Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/LIFE13102050"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00196-X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRETEYERES.2006.05.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNE.903560109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2020.00161\/BIBTEX"},{"key":"e_1_2_11_7_1","first-page":"14904","article-title":"Original article a convenient method for quantifying collagen fibers in atherosclerotic lesions by ImageJ software","volume":"10","author":"Chen Y.","year":"2017","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01800-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BRAINRESBULL.2005.08.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00973-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV-IMMUNOL-051116-052358"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025791512555\/METRICS"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1267\/AHC.08034"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0044711"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2954721"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-021-94992-X"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12035-015-9122-5"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/78774"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES10050939\/S1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNCEL.2015.00484\/BIBTEX"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/DNEU.22081"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00441-003-0785-2"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS20092364"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070255"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3162-11.2011"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EXER.2016.02.001"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523803206015"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000814)424:1<1::AIDCNE1>3.0.CO;2-V"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/DB10-1160"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/BBRC.1996.1112"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00040-0"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/AR.22641"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1167\/TVST.11.11.17"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRETEYERES.2014.11.004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1644\/864.1"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NBD.2022.105684"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M109.052969"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS20092229"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2011.04.001"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0073323"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SEMCDB.2020.06.005"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0192355"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0164164"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095252380219506X"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/JNR.20354"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2023.1227116"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEULET.2013.10.037"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1167\/IOVS.14-14051"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/DNEU.20928"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EXER.2016.01.011"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BRAINRESBULL.2007.10.026"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1242\/DEV.116.1.201"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02703642\/METRICS"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(96)10040-0"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/GLIA.23078"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHOPHT.1986.01050210137041"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1986.189.09.1035"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.13139\/SUPPINFO"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11259-019-09767-7"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11259-019-9745-5"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13041-014-0053-2\/FIGURES\/7"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800000031"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBADIS.2015.11.014"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00401-015-1513-1"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.31083\/J.FBL2706169"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROSCIENCE.2007.07.059"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)90024-8"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/GLIA.22477"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90412-G"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A004051"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59643"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00345-1\/ASSET\/5B862735-2751-4109-9358-D6296475D5A5\/MAIN.ASSETS\/GR8.SML"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12035-014-9070-5"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1460-9568.2008.06322.X"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0096801"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRETEYERES.2015.06.003"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4385-06.2007"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17383"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800174097"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNE.903320403"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23683"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/BJO.87.9.1159"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS10061339"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/SREP07130"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNANA.2017.00077\/BIBTEX"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.25682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ar.25682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.25682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:43:23Z","timestamp":1769719403000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.25682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ar.25682"],"URL":"https:\/\/doi.org\/10.1002\/ar.25682","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"value":"1932-8486","type":"print"},{"value":"1932-8494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"2024-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}