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Previous studies have shown that the expression of the transcription factor SOX9 in these cell populations is essential in the regulation of this process. SOX9 interacts with other SOX family members including SOX5 and SOX6 to cooperatively regulate other developmental events. Although SOX6 has documented roles in the postnatal heart, its role in cardiac development has not yet been examined. For the current study we decided to investigate the importance of SOX6 in valvuloseptal morphogenesis. Expression studies revealed that SOX6 is expressed in many of the cell lineages that contribute to the formation of the heart. Given the pattern of SOX6 expression in the endocardium and endocardial\u2010derived cells as well as in the coronary endothelium, we focused on the role of SOX6 in these cell populations by generating endothelial\/endocardial\u2010specific\n                    <jats:italic>Sox6<\/jats:italic>\n                    knockout mice. These conditional knockout mice presented with ventricular septal defects, enlarged atrioventricular valves, and coronary abnormalities. Cardiovascular defects observed in the endothelial\/endocardial\u2010specific\n                    <jats:italic>Sox6<\/jats:italic>\n                    knockout mouse demonstrate that SOX6 plays an important role in valvuloseptal development.\n                  <\/jats:p>","DOI":"10.1002\/ar.70285","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:00:37Z","timestamp":1783587637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SOX6<\/scp>\n                    is expressed in various cell lineages in the developing mouse heart and contributes to proper valvuloseptal development"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-2605","authenticated-orcid":false,"given":"Hannah G.","family":"Tarolli","sequence":"first","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inara","family":"Devji","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond N.","family":"Deepe","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna R.","family":"Drummond","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9lyn A.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-9361","authenticated-orcid":false,"given":"Andy","family":"Wessels","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401711101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213x-11-59"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166574"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13973"},{"key":"e_1_2_9_6_1","first-page":"313","article-title":"Epithelial\u2010mesenchymal transformation in chick atrioventricular cushion morphogenesis","volume":"3","author":"Bolender D. 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