{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:56:15Z","timestamp":1791266175608,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Meissner corpuscles are rapidly adapting mechanoreceptors involved in tactile discrimination in human glabrous hand skin. Detailed information on their regional distribution and variation across age, sex, and hand side remains limited. This study mapped Meissner corpuscles in 17 phalangeal and palmar regions from 46 individuals (27 male and 19 female) aged 3\u201392\u2009years. Corpuscles were identified by S100 protein immunoreactivity. Density, the Meissner corpuscle index relative to dermal papillae, and equivalent circular diameter (ECD) were assessed using prespecified morphometric procedures. Descriptive comparisons were made across 17 hand regions. For distal\u2010phalanx density, a secondary aggregate\u2010level analysis compared 20 matched means per age group (five digits\u2009\u00d7\u2009two sexes\u2009\u00d7\u2009two hands). Density was higher in all 20 combinations in both consecutive age\u2010group comparisons before 40\u2009years and lower in all 20 in both comparisons after 40\u2009years (exact two\u2010sided sign\u2010test\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.91\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    ; Holm\u2010adjusted\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20097.63\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    for each comparison). Sex\u2010 and hand\u2010side analyses showed no consistent directional pattern among the aggregate means (all Holm\u2010adjusted\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.000). The Meissner corpuscle index was descriptively highest in the 21\u2010 to 40\u2010year group, whereas ECD was higher in the 21\u2010 to 40\u2010 and 41\u2010 to 60\u2010year groups and markedly lower after 60\u2009years. The study provides a detailed anatomical map and identifies a uniform age\u2010related directional pattern in the retained aggregate distal\u2010phalanx data. Because subject\u2010level observations were unavailable for reanalysis, the statistical findings quantify directional consistency among aggregate means and should not be interpreted as subject\u2010level inference.\n                  <\/jats:p>","DOI":"10.1002\/ar.70368","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:40:18Z","timestamp":1791265218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the distribution of Meissner corpuscles throughout the human hand: Sex\u2010 and age\u2010dependent variations"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-9163","authenticated-orcid":false,"given":"Irene","family":"Amigo","sequence":"first","affiliation":[{"name":"Servicio de Traumatolog\u00eda y Cirug\u00eda Ortop\u00e9dica Hospital Universitari Son Espases  Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Garc\u00eda\u2010Mesa","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Universidad de Oviedo  Oviedo Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Cuendias","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Universidad de Oviedo  Oviedo Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Feito","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Universidad de Oviedo  Oviedo Spain"},{"name":"Servicio de Anatom\u00eda Patol\u00f3gica Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL)  Salamanca Spain"},{"name":"Departamento de Biolog\u00eda Celular y Patolog\u00eda Universidad de Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Garc\u00eda\u2010Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Universidad de Oviedo  Oviedo Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Suazo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Aut\u00f3noma de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulima","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Matem\u00e1ticas Universidad de Oviedo  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Universidad de Oviedo  Oviedo Spain"},{"name":"Facultad de Ciencias de la Salud Universidad Aut\u00f3noma de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000114887"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.051"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.1999.1171"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"30","article-title":"Density and structural variations of Meissner corpuscles at different sites in human glabrous skin","volume":"57","author":"Bhat G.","year":"2008","journal-title":"Journal of the Anatomical Society of India"},{"key":"e_1_2_11_7_1","first-page":"190","article-title":"A quantitative study of Meissner corpuscles in man","volume":"89","author":"Bolton C. 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