{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:51:06Z","timestamp":1791287466827,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE031439"],"award-info":[{"award-number":["DE031439"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE029832"],"award-info":[{"award-number":["DE029832"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anatomypubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Anatomical Record"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sequence variations in fibroblast growth factor receptor 2 (FGFR2) are associated with craniosynostosis syndromes, disrupting craniofacial development, yet early mandibular alterations remain poorly characterized. This study examined Meckel's cartilage (MC) and mandibular morphology in mouse models of Apert (\n                    <jats:italic>Fgfr2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/P253R<\/jats:italic>\n                    <\/jats:sup>\n                    ) and Crouzon (\n                    <jats:italic>Fgfr2c<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>C342Y\/+<\/jats:italic>\n                    <\/jats:sup>\n                    ) syndromes using Euclidean distance matrix analysis and finite element modeling at embryonic days 14.5 and 16.5. Apert mice exhibited significant MC shortening and elevated, widespread strain in the growth center area correlating with mandibular shortening and asymmetry. In contrast, Crouzon mice showed minor MC changes and localized strain peaks with larger mandibles. These biomechanical perturbations in Meckel's cartilage are associated with distinct mandibular phenotypes, consistent with a bidirectional relationship in which altered strain environments may both influence and reflect mandibular dysmorphogenesis during early development. The findings enhance our understanding of the biomechanical basis of mandibular anomalies associated with FGFR2 mutations, informing future investigations into craniofacial morphogenesis.\n                  <\/jats:p>","DOI":"10.1002\/ar.70371","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:57:10Z","timestamp":1791284230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomechanical strain patterns in Meckel's cartilage underlie mandibular variation in\n                    <scp>FGFR2<\/scp>\n                    mouse models"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7545-3733","authenticated-orcid":false,"given":"Fred R.","family":"Foster","sequence":"first","affiliation":[{"name":"Department of Anthropology The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-0896","authenticated-orcid":false,"given":"Alexandre","family":"Freire","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8718-4898","authenticated-orcid":false,"given":"Ana Cl\u00e1udia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-4596","authenticated-orcid":false,"given":"Jordan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Anthropology The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0239-5822","authenticated-orcid":false,"given":"Joan T.","family":"Richtsmeier","sequence":"additional","affiliation":[{"name":"Department of Anthropology The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1090-5340","authenticated-orcid":false,"given":"Kazuhiko","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Anthropology The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-6915","authenticated-orcid":false,"given":"Felippe B.","family":"Prado","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3412-221X","authenticated-orcid":false,"given":"Susan M. Motch","family":"Perrine","sequence":"additional","affiliation":[{"name":"Department of Anthropology The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Penn State College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Medicine Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"67934","DOI":"10.18632\/oncotarget.11982","article-title":"Chromatin determinants of the inner\u2010centromere rely on replication factors with functions that impart cohesion","volume":"7","author":"Abe T.","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1016\/j.jbiomech.2015.07.017","article-title":"Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development","volume":"48","author":"Brunt L. 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