{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:26:44Z","timestamp":1767986804112,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,3,19]],"date-time":"2003-03-19T00:00:00Z","timestamp":1048032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Collagen fiber orientation is one aspect of the microstructure of bone that influences its mechanical properties. While the spatial distribution of preferentially oriented collagen is hypothesized to reflect the effects of loading during the process of aging, its variability in a modern human sample is essentially unknown. In a large sample (n = 67) of autopsied adults, the variability of collagen fiber orientation in the mid\u2010shaft femur was examined in relation to age and sex. Montaged images of entire 100 \u03bcm thick cross\u2010sections were obtained using circularly polarized light microscopy (CPLM) under standardized illuminating conditions. An automated image\u2010analyzing routine divided images into 48 segments according to anatomical position. Average gray values (varying with orientation) were quantified for each segment, and one\u2010way ANOVA with Tukey HSD post hoc tests were applied to assess differences between segments. Collagen fiber orientation appeared to be nonrandomly distributed across the mid\u2010shaft femur sample; however, no single \u201chuman\u201d pattern was identified. Individual variation, unexplainable by age, sex, or body size, exceeded population\u2010level trends. Differences between age and sex groups suggest there is a strong correspondence between collagen fiber orientation and tissue\u2010type distributions. The minimal consistencies demonstrated here may reflect mechanical forces induced at the femoral mid\u2010shaft. However, the myriad of other factors that may influence collagen fiber orientation patterning, including growth trajectories, metabolic and nutritional status, and disease states, must be explored further. Only then, in conjunction with studies of other structural and material properties of bone, will we be able to elucidate the linkages between microstructure and functional adaptation in the human mid\u2010shaft femur. Anat Rec Part A 272A:434\u2013445, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.a.10055","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T11:02:49Z","timestamp":1050404569000},"page":"434-445","source":"Crossref","is-referenced-by-count":72,"title":["Preferred collagen fiber orientation in the human mid\u2010shaft femur"],"prefix":"10.1002","volume":"272A","author":[{"given":"Haviva M.","family":"Goldman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G.","family":"Bromage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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